BIOPHYSICAL CHANNEL MODELS OF ASSOCIATIVE LEARNING

联想学习的生物物理通道模型

• 批准号: 2674372
• 负责人: Kim L Blackwell
• 金额: $ 11.02万
• 依托单位: GEORGE MASON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1995
• 资助国家: 美国
• 起止时间: 1995-09-01 至 2000-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2674372
• 关键词: GABA receptor; Hermissenda; action potentials; alternatives to animals in research; association learning; behavioral /social science research tag; calcium flux; computational neuroscience; conditioning; light intensity; mathematical model; memory; molecular psychobiology; neural information processing; neural plasticity; photostimulus; potassium channel; visual phototransduction

This is a request for a Scientist Development Award. The goal of the proposed research is to begin to understand, in quantitative detail, mechanisms of learning and memory in Hermissenda crassicornis, an invertebrate marine snail that shares behavioral characteristics and biophysical and biochemical mechanisms of learning and memory with mammals. Hermissenda demonstrates associative learning in response to paired presentations of light (Conditioned Stimulus) and turbulence (Unconditioned Stimulus). Acquisition and storage of this memory occurs m the medial B photoreceptor cell, the site of convergence of the light-evoked signal and the turbulence-evoked signal. Although the long term changes in the B cell membrane corresponding to memory storage have been characterized essential details of some of the biophysical mechanisms underlying associative learning are still unknown, and the CS and UCS interactions leading to the behavioral characteristics of associative learning are not completely understood. To achieve an in-depth understanding of some of these essential issues, the research plan describes an inter-related series of biophysical experiments and mathematical modeling organized around the following three questions: (1) What properties of the light induced currents makes stimulus coding sufficiently sensitive to permit the degree of stimulus specificity seen in Hermissenda? (2) Are there pre-synaptic mechanisms, as well as post-synaptic mechanisms, underlying the learning induced change in the effect of hair cell stimulation on the B photoreceptor? (3) What is the functional role of each of the currents, and of interactions among currents with respect to behavioral characteristics of classical conditioning? The biophysical experiments and mathematical modeling required to address these issues are necessary and sufficient training to enable me to become an independent investigator and to make significant contributions in the field of computational neuroscience. Quantitative understanding of biophysical and biochemical interactions underlying association learning in Hermissenda produced by the proposed research also will contribute to understanding of associative learning in mammals. Development of concise mathematical descriptions of the channel models would make possible the formulation of improved learning rules, network architectures and neuronal elements in artificial neural networks.

这是获得科学家发展奖的要求。目标的目标 拟议的研究是开始从定量的细节中理解 Hermissenda crassicornis的学习和记忆机制， 无脊椎动物海洋蜗牛具有行为特征和 与学习和记忆的生物物理和生化机制 哺乳动物。 hermissenda表现出协会学习的回应 光（条件刺激）和湍流的配对演示 （无条件的刺激）。 发生此内存的获取和存储 内侧B 感光细胞，光诱发信号的收敛位点 和湍流引起的信号。尽管长期变化 与存储器存储相对应的B细胞膜已被表征 一些生物物理机制的基本细节 协会学习仍然未知，CS和UCS互动 导致联想学习的行为特征不是 完全理解。 要深入了解一些 这些基本问题，研究计划描述了相互关联的 组织的一系列生物物理实验和数学建模组织 围绕以下三个问题：（1）光的特性 诱导电流使刺激编码足够敏感以允许 在Hermissenda中看到的刺激特异性程度？ （2）在那里 突触前机制以及突触后机制，基础 学习引起的毛细胞刺激对 B感光器？ （3）每种电流的功能作用是什么， 以及电流之间相对于行为的相互作用 经典条件的特征？生物物理实验 解决这些问题所需的数学建模是必要的 并足够的培训使我成为独立的 调查人员并在该领域做出重大贡献 计算神经科学。 对生物物理的定量理解 和生化互动的基础关联学习中的学习 拟议研究产生的hermissenda也将有助于 了解哺乳动物中的联想学习。简洁的发展 通道模型的数学描述将使 制定改进的学习规则，网络体系结构和 人工神经网络中的神经元素。