ACTH SENSITIVITY/RESPONSIVITY IN AGING

衰老过程中 ACTH 的敏感性/反应性

• 批准号: 6274053
• 负责人: Charles RICHARD PARKER
• 金额: $ 2.59万
• 依托单位: UNIVERSITY OF ALABAMA AT BIRMINGHAM
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-01-26 至 1998-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6274053
• 关键词: African American; adrenal disorder; adrenal glands; adrenocorticotropic hormone; age difference; aging; clinical research; human subject; steroid biosynthesis

Aging in humans is associated with a striking deficiency in adrenal production of androgens. Reduced levels of adrenal androgens have been correlated with increased indicence of many sequelae of aging such as cardiovascular disease, cancer, insulin resistance, hyperlipidemia, and impaired immune competence. The mechanisms for age-associated reductions in adrenal androgen production are unknown. It also is not clear if aging effects adrenal function in men and women in similar manners or whether there are race related differences in adrenal function in young or elderly humans. We propose to continue our studies on the effect of aging on the adrenal steroid biosynthetic pathway, particularly in aging African Americans, in whoem little is established regarding adrenal corticosteroid or androgen production. These studies will be condectted by means of dynamic functional testing of adrenal responses to graded doses of ACTH in aged men and women compared to young adults. The results of these studies are expected to provide both a characterization of adrenal function in aged adults and also to suggest the mechanisms whereby such function is altered in normal aging adults. The impact of hormone replacement therapy in postmenopausal women on adrenal steroidogenic responses also will be determined.

人类的衰老与肾上腺素的显着缺乏有关 雄激素的产生。肾上腺雄激素水平降低 与许多衰老后遗症的发生率增加相关，例如 心血管疾病、癌症、胰岛素抵抗、高脂血症等 免疫能力受损。 与年龄相关的减少机制 肾上腺雄激素产生的作用尚不清楚。也不清楚是否老化 以相似的方式影响男性和女性的肾上腺功能，或者是否 年轻人或老年人的肾上腺功能存在种族相关差异 人类。 我们建议继续研究衰老对 肾上腺类固醇生物合成途径，特别是在非洲老年人中 美国人对肾上腺皮质类固醇知之甚少 或雄激素的产生。 这些研究将通过 肾上腺对分级剂量 ACTH 反应的动态功能测试 老年男性和女性与年轻人相比。 这些研究的结果 预计将提供肾上腺功能的表征 老年人，并提出这种功能的机制 正常老年人发生改变。 激素替代疗法的影响 绝经后妇女对肾上腺类固醇激素的反应也会 决定。