DST/CSA IN NONHLA IDENTICAL LIVE DONOR TXP/CADAVER RENAL ALLOGRAFT/BONE MARROW

非NHLA相同活体捐献者TXP/尸体同种异体肾移植物/骨髓中的DST/CSA

• 批准号: 6274040
• 负责人: ARNOLD G DIETHELM
• 金额: $ 2.59万
• 依托单位: UNIVERSITY OF ALABAMA AT BIRMINGHAM
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-01-26 至 1998-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6274040
• 关键词: artificial immunosuppression; blood transfusion; bone marrow transplantation; clinical research; clinical trials; cyclosporines; haploidy; human subject; human therapy evaluation; immune tolerance /unresponsiveness; kidney transplantation; postmortem; tissue donors; transplant rejection

Cooperative Clinical Trials in Transpantation is a multi-center trial funded by an NIH grant with two protocols currently having IRB approval, "Pre- and Posttransplant Donor Specific Transfusion/Cyclosporine A in Non- HLA Identical Living Related Kidney Transplant Recipients" and "Cadaver Renal Allograft and Bone Marrow Transfusion". The purpose of these studies includes assessing the effectiveness of a donor specific transfusion/Cyclosporine A protocol to induce donor specific unresponsiveness in recipients of kidneys from one or zero haplotype matched donors and determining the safety and benefit in terms of lessened rejection and graft survival from the administration of donor bone marow cells to recipients of cadaveric renal transplants. One of the measures of graft function is GFR. For this protocol, measurement is obtained at 3, 12 and 24 months using Iohexol. This outpatient procedure involves injection of the Iohexol followed by blood sampling at 2, 3, and 4 hours post Iohexol injection. The samples are then mailed to the central lab in Minnesota. This particular measurement of GFR is not routinely used at UAB, but Iohexol administration and blood sampling could be done at the GCRC.

转移的合作临床试验是一项多中心试验 由NIH赠款资助，并具有目前具有IRB批准的两个协议， “在非 - HLA相同的与生活相关的肾脏移植接受者”和“尸体 肾脏同种异体移植和骨髓输血”。 研究包括评估捐赠者特定的有效性 输血/环孢菌素A诱导供体特异的方案 从一个或零单倍型的肾脏接受者无反应 匹配的捐助者并确定减少的安全性和利益 供体骨摩托给药的排斥和移植生存 细胞到尸体肾移植的受体。 其中之一 移植功能是GFR。 对于此协议，在 3、12和24个月使用iohexol。 此门诊程序涉及 注射iohexol，然后在2、3和4小时内进行血液采样 iohexol注射后。 然后将样品邮寄到中央实验室 明尼苏达州。 GFR的这种特殊测量不常规使用 UAB，但可以在 GCRC。