DONOR SPECIFIC TRANSFUSION/CYCLOSPORINE A

供体特异性输血/环孢菌素 A

• 批准号: 5215669
• 负责人: ARNOLD G DIETHELM
• 金额: --
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/5215669
• 关键词: blood transfusion; bone marrow transplantation; clinical research; cyclosporines; haploidy; human subject; human therapy evaluation; immunosuppressive; kidney transplantation; postmortem; postoperative state; preoperative state; tissue donors; transplantation immunology

The is a pre- and posttransplant donor specific transfusion/cyclosporine A in non-HLA identical living related kidney transplant recipients and cadaver renal allograft and bone marrow transfusion protocol to assess the effectiveness of donor specific blood transfusions to induce donor specific unresponsiveness in recipients of kidneys from one- or zero- haplotype matched donors. The cadaver bone marrow study is designed to evaluate the effect of cadaver marrow transfusions given with renal transplantation in conjunction with immunosuppressive agents. We will also evaluate the immunologic impact of the therapy.

这是移植前和移植后供体特异性输血/环孢菌素 a在非HLA相同的生活相关肾脏移植受者中 尸体肾脏同种异体移植和骨髓输血方案评估 供体特异性输血的有效性诱导供体 来自一或零的肾脏接受者的特定无反应性 单倍型匹配的捐助者。 尸体骨髓研究设计为 评估用肾脏输血的尸体输血的效果 与免疫抑制剂一起移植。我们将 还评估治疗的免疫学影响。