TUBERCULOSIS IN A MULTIETHNIC CITY POPULATION

多民族城市人口中的结核病

• 批准号: 6115704
• 负责人: MICHAEL MARMOR
• 金额: $ 2.1万
• 依托单位: NEW YORK UNIVERSITY SCHOOL OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-12-01 至 1999-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6115704
• 关键词: HIV infections; Mycobacterium tuberculosis; adult human (21+); behavioral /social science research tag; chemoprevention; child (0-11); clinical research; clinical trials; disease /disorder proneness /risk; epidemiology; ethnic group; genetic strain; human subject; human therapy evaluation; intravenous drug abuse; microorganism disease chemotherapy; opportunistic infections; pathologic process; therapy compliance; tuberculosis; urban area

This protocol will determine the incidence of Mycobacterium tuberculosis (M tb) infection in HIV-infected and -uninfected injecting drug users (IDUs), sexual partners of IDUs, and children in contact with TB-infected adults. It will identify environmental and host risk factors for developing M tb infection; describe the natural history of M tb disease in children and adults; investigate the epidemiology of specific strains of M tb; evaluate the effect of M tb coinfection on the rate of progression of HIV disease; and investigate factors influencing compliance with tuberculosis prophylaxis and therapy. The lab was used for blood separation, DNA isolation, ELISA, PCR, RNA isolation, and sample storage.

该方案将确定艾滋病毒感染和未感染的注射吸毒者（IDU），IDUS的性伴侣以及与TB感染的成年人接触的儿童的结核分枝杆菌感染（M TB）感染的发生率。它将确定发展M TB感染的环境和宿主风险因素；描述儿童和成人中M TB疾病的自然史；研究M TB特异性菌株的流行病学；评估M TB共感染对HIV疾病进展率的影响；并研究影响预防结核病和治疗的因素。 该实验室用于血液分离，DNA分离，ELISA，PCR，RNA分离和样品存储。