RESOLVING HETEROGENEITY IN EPILEPSY USING GENETIC MARKERS

使用遗传标记解决癫痫的异质性

• 批准号: 6246217
• 负责人: DAVID A. GREENBERG
• 金额: $ 4.47万
• 依托单位: MOUNT SINAI SCHOOL OF MEDICINE OF CUNY
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-03-12 至 1997-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6246217
• 关键词: clinical research; electroencephalography; epilepsy; family genetics; genetic markers; human subject; linkage mapping; major histocompatibility complex; myoclonus epilepsy; neurogenetics

The purpose of this study is to confirm linkage between JME, the EEG traits seen in clinically unaffected family members and genetic markers in the vicinity of the HLA locus and to test whether other forms of epilepsy, specifically those non-JME forms of epilepsy seen in JME families, are genetically related to JME at the chromosome 6 locus.

本研究的目的是确认 JME、EEG 之间的联系 在临床上未受影响的家庭成员中观察到的特征和遗传标记 HLA 基因座附近并测试是否有其他形式的癫痫， 特别是 JME 家族中出现的非 JME 形式的癫痫， 与 6 号染色体位点的 JME 遗传相关。