VASOCONSTRICTION DURING COLD PRESSOR TEST--ALPHA ADRENERGIC BLOCKADE

冷加压试验期间的血管收缩--α肾上腺素能阻断

• 批准号: 6245394
• 负责人: STEVEN FRANK
• 金额: $ 2.23万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-03-05 至 1997-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6245394
• 关键词: alpha adrenergic agent; cardiovascular pharmacology; clinical research; cold temperature; heart rate; human subject; phentolamine; vasoconstriction

Over the last 3 years since the study has begun we have completed the portion of the study addressing alpha-antagonists and the response to the cold pressor test. The data show that the peripheral vasoconstriction response is attenuated by phentolamine. These results have been previously published (in 1994) and were included in last years GCRC report. The GCRC grant was acknowledged in these abtracts and papers. The other aim in this study was to assess the effects of alpha- adrenergic antagonism on the vasomotor and metabolic mechanisms that maintain norniothermia in the absence of cold stress. These studies were also completed and were published in abstract as well as manuscript form. The findings indicate that alpha-antagonists decrease vasomotor tone, increase heat loss through the skin, which results in a lower core temperature. There is also a dose-response that we have shown for these effects. One additional area of interest was that of heart rate variability. Working with Lee Fleisher in the Dept. of Anesthesiology, we were able to describe the effects of core hypothermia on changes in heart rate variability in human subjects. We showed increased low frequency power in the spectral analysis for R to R interval variability.

自从研究开始以来的过去三年中，我们已经完成了 研究的一部分是针对α-抗逆邦攻击者的 冷压测试。 数据显示外围 血管收缩反应会被苯丙胺减弱。 这些结果 以前已发表（1994年），并在去年包括 GCRC报告。 在这些成分中确认了GCRC赠款， 文件。 这项研究的另一个目的是评估α- 肾上腺素能的拮抗作用在血管舒缩和代谢机制上 在没有冷应力的情况下，保持非热室。 这些研究 也完成并以摘要和手稿发表 形式。 研究结果表明，α-抗逆邦剂减少了血管舒缩剂 音调，增加皮肤的热量损失，从而导致较低的核心 温度。 我们还显示了这些剂量反应 效果。 感兴趣的另一个领域是心率变异性。 与李·弗利什（Lee Fleisher）在麻醉学系合作，我们能够 描述核心体温过低对心率变化的影响 人类受试者的变异性。 我们显示低频功率增加 在r间隔变异性的光谱分析中。