COMPARATIVE MEDICINE RESEARCH CENTER

比较医学研究中心

• 批准号: 2431413
• 负责人: JOSEPH E WAGNER
• 金额: $ 32.71万
• 依托单位: UNIVERSITY OF MISSOURI-COLUMBIA
• 依托单位国家: 美国
• 财政年份: 1993
• 资助国家: 美国
• 起止时间: 1993-06-01 至 1999-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2431413
• 关键词: animal welfare research; communicable diseases; epizootiology; veterinary medicine

The long-term objective of the Comparative Medicine Research Center in the Department of Veterinary pathology at University of Missouri-Columbia is to enhance advances in biomedical research and thereby improve the human condition by improving the quality and definition of laboratory animals through basic and applied biomedical research related to laboratory animal medicine, pathology, and science. Historically, progress in biomedical research has involved animals. Animals are used in about half of all research funded by the NIH. By improving our understanding of the biology, pathophysiology, diseases, and research uses of the animal 'reagent' more meaningful extrapolation of animal derived data to human health and disease will be possible. Our specific aims include: 1) focused investigations to provide understanding and possible solutions to major contemporary problems affecting the use of animals in research; 2) dissemination of this information through appropriate publications and presentations; and 3) to assist in the application of our research findings. Another aim is to provide research training opportunities and to encourage education in the broad area of laboratory animal science. We have identified six major problems that affect the use of animals in research and in this proposal we present designs of research projects for their study under the following project titles: -- Rodent Orphan Pathoviruses: Molecular Characterization and Development of Diagnostic Reagents -- Rodent Orphan Pathoviruses: Pathogenesis and Interface with Research -- The biology of the Intestinal, Segmented, Filamentous Bacteria of Rodents -- Production of Specific Viral Antigens for Use as Diagnostic Reagents Using a Baculovirus Expression System -- Viral Gene Amplification Assays of detection of Murine Viruses in Biological Samples --Pathogenesis of Cilia-Associated Respiratory Bacillus Infection

比较医学研究中心的长期目标 密苏里大学哥伦比亚分校兽医病理学系 旨在促进生物医学研究的进步，从而提高 通过提高实验室的质量和定义来改善人类状况 通过与动物相关的基础和应用生物医学研究 实验动物医学、病理学和科学。 从历史上看， 生物医学研究的进展涉及动物。 使用动物 大约一半的研究由 NIH 资助。 通过改善我们的 了解生物学、病理生理学、疾病和研究 使用动物“试剂”对动物进行更有意义的推断 获取有关人类健康和疾病的数据将成为可能。 我们的具体 目标包括：1）集中调查以提供理解和 影响使用的当代主要问题的可能解决方案 研究中的动物； 2）通过以下方式传播此信息 适当的出版物和演示； 3) 协助 我们的研究成果的应用。 另一个目的是提供研究 培训机会并鼓励广泛领域的教育 实验动物科学。 我们已经确定了影响动物使用的六大问题 研究，在本提案中，我们提出了研究项目的设计 他们的研究项目如下： -- 啮齿动物孤儿病理病毒：分子特征和 诊断试剂的开发 -- 啮齿动物孤儿致病病毒：发病机制及其与研究的相互作用 -- 肠道分节丝状细菌的生物学 啮齿类动物 -- 生产用作诊断试剂的特异性病毒抗原 使用杆状病毒表达系统 -- 病毒基因扩增试验检测小鼠病毒 生物样本 --纤毛相关呼吸道杆菌感染的发病机制

项目成果

Molecular characterization of newly recognized rodent parvoviruses.

新识别的啮齿动物细小病毒的分子特征。

• DOI: 10.1099/0022-1317-77-5-899
• 发表时间: 1996
• 期刊: The Journal of general virology.
• 作者: Besselsen,DG;Pintel,DJ;Purdy,GA;Besch-Williford,CL;Franklin,CL;HookJr,RR;Riley,LK
• 通讯作者: Riley,LK

Failure of a soiled bedding sentinel system to detect cilia-associated respiratory bacillus infection in rats.

脏寝具哨兵系统未能检测大鼠纤毛相关呼吸道杆菌感染。

• 发表时间: 1995
• 期刊: Laboratory animal science.
• 作者: Cundiff,DD;Riley,LK;Franklin,CL;HookJr,RR;Besch-Williford,C
• 通讯作者: Besch-Williford,C

Detection of rodent parvoviruses by PCR.

通过 PCR 检测啮齿动物细小病毒。

• DOI: 10.1385/0-89603-497-6:31
• 发表时间: 1998
• 期刊: Methods in molecular biology (Clifton, N.J.)
• 作者: Besselsen,DG

Natural and experimentally induced infection of Syrian hamsters with a newly recognized parvovirus.

叙利亚仓鼠自然和实验诱导感染一种新识别的细小病毒。

• 发表时间: 1999
• 期刊: Laboratory animal science.
• 作者: Besselsen,DG;Gibson,SV;Besch-Williford,CL;Purdy,GA;Knowles,RL;Wagner,JE;Pintel,DJ;Franklin,CL;HookJr,RR;Riley,LK
• 通讯作者: Riley,LK

Characterization of lymphocyte subsets in the bronchiolar lymph nodes of BALB/c mice infected with cilia-associated respiratory bacillus.

感染纤毛相关呼吸道杆菌的 BALB/c 小鼠细支气管淋巴结淋巴细胞亚群的特征。

• 发表时间: 2002
• 期刊: Comparative medicine
• 影响因子: 0.8
• 作者: Kendall,LonV;Riley,LelaK;HookJr,ReuelR;Besch-Williford,CynthiaL;Franklin,CraigL
• 通讯作者: Franklin,CraigL