COMPARATIVE MEDICINE RESEARCH CENTER

比较医学研究中心

• 批准号: 3100466
• 负责人: JOSEPH E WAGNER
• 金额: $ 27.24万
• 依托单位: UNIVERSITY OF MISSOURI-COLUMBIA
• 依托单位国家: 美国
• 财政年份: 1993
• 资助国家: 美国
• 起止时间: 1993-06-01 至 1998-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3100466
• 关键词: animal welfare research; communicable diseases; epizootiology; veterinary medicine

The long-term objective of the Comparative Medicine Research Center in the Department of Veterinary Pathology at the University of Missouri- Columbia is to enhance advances in biomedical research and thereby improve the human condition by improving the quality and definition of laboratory animals through basic and applied biomedical research related to laboratory animal medicine, pathology, and science. Historically, progress in biomedical research has involved animals. Animals are used in about half of all research funded by the NIH. By improving our understanding of the biology, pathophysiology, diseases, and research uses of the animal "reagent" more meaningful extrapolation of animal derived data to human health and disease will be possible. Our specific aims include; 1) focused investigations to provide understanding and possible solutions to major contemporary problems affecting the use of animals in research; 2) dissemination of this information through appropriate publications and presentations; and 3) to assist in the application of our research findings. Another aim is to provide research training opportunities and to encourage education in the broad area of laboratory animal science. We have identified six major problems that affect the use of animals in research and in this proposal we present designs of research projects for their study under the following project titles: 1) Rodent Orphan Parvoviruses: Molecular Characterization and Development of Diagnostic Reagents, 2) Rodent Orphan Parvoviruses: Pathogenesis and Interference with Research, 3) The biology of the Intestinal, Segmented, Filamentous Bacteria of Rodents, 4) Production of Specific viral Antigens for Use as Diagnostic Reagents Using a Baculovirus Expression System, 5) Viral Gene Amplification Assays for Detection of Murine Viruses in Biological Samples, and 6) Pathogenesis of Cilia-Associated Respiratory Bacillus Infection. A CORE Support Unit is requested to provide administrative services and a limited amount of institutional research-related laboratory animal diagnostic problem solving services for its research program to identify animal health problems.

比较医学研究中心的长期目标 密苏里大学兽医病理学系 哥伦比亚大学致力于促进生物医学研究的进步，从而 通过提高质量和定义来改善人类状况 通过基础和应用生物医学研究相关的实验动物 实验动物医学、病理学和科学。 从历史上看， 生物医学研究的进展涉及动物。 使用动物 大约一半的研究由 NIH 资助。 通过改善我们的 了解生物学、病理生理学、疾病和研究 使用动物“试剂”对动物进行更有意义的推断 获取有关人类健康和疾病的数据将成为可能。 我们的具体 目标包括； 1）集中调查以提供理解和 影响使用的当代主要问题的可能解决方案 研究中的动物； 2）通过以下方式传播此信息 适当的出版物和演示； 3) 协助 我们的研究成果的应用。 另一个目标是提供 研究培训机会并鼓励广泛的教育 实验动物科学领域。 我们已经确定了影响动物使用的六大问题 研究，在这个提案中我们提出了研究项目的设计 他们在以下项目名称下进行研究：1）啮齿动物孤儿 细小病毒：分子特征和诊断方法的发展 试剂，2) 啮齿动物孤儿细小病毒：发病机制和干扰 与研究，3) 肠的生物学，分段的，丝状的 啮齿动物的细菌，4) 用作特定病毒抗原的生产 使用杆状病毒表达系统的诊断试剂，5) 病毒基因 生物制品中鼠病毒检测的扩增分析 样本，以及 6) 纤毛相关呼吸道杆菌的发病机制 感染。 要求设立一个核心支持单位来提供行政服务和 数量有限的机构研究相关实验动物 为其研究计划确定诊断问题解决服务 动物健康问题。