REPOLARIZATION CHANGES ASSOCIATED WITH VENTRICULAR ARRHYTHMIAS AND SUDDEN DEATH

与室性心律失常和猝死相关的复极变化

• 批准号: 6242377
• 负责人: Jay W. Mason
• 金额: $ 18.77万
• 依托单位: UNIVERSITY OF UTAH
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-01-01 至 1997-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6242377
• 关键词: antiarrhythmic agent; computer simulation; disease /disorder model; dogs; electrocardiographic monitor; electrophysiology; exercise; heart disorder chemotherapy; heart pharmacology; human subject; human therapy evaluation; longitudinal human study; myocardial ischemia /hypoxia; phenylalkylamine; prognosis; sudden cardiac death; tachycardia; ventricular fibrillation

Project 3 is a clinically oriented examination of repolarization changes that precede ventricular tachycardia and ventricular fibrillation. Experiments will be performed in both dogs and patients. Project 3 contains three subprojects: Project 3.1, Repolarization Changes Immediately Preceding Ischemic Sudden Death: Project 3.2, Repolarization Changes Immediately Preceding Sustained Ventricular Tachycardia; and Project 3.3, Repolarization Change as a Predictor of Outcome in the ESVEM Trial. The three subprojects are unified by a general hypothesis: Repolarization changes precede and may be causative of ventricular tachyarrhythmias. In Project 3.1 we will examine the nature and extent of repolarization changes during acute myocardial infarction as reflected by the QT interval, the activation-recovery interval and the QRST integral. We will determine the extent to which a change in resting potential is responsible for alteration in QRST integral. A system for recording repolarization changes chronically in man will be validated. In Project 3.2 we will measure repolarization changes occurring immediately before onset of sustained ventricular tachycardia in patients enrolled in the ESVEM Trial using an automated analysis of Holter tape recordings. In Project 3.3 we will use the same capability and patient population to evaluate the prognostic significance of variability of repolarization duration, and the relationship between change in that variability.

项目3是对复极变化的临床检验 这是心室心动过速和心室纤颤之前的。 将在狗和患者中进行实验。 项目3 包含三个子项目：项目3.1，重极化变化 紧接缺血性突然死亡：项目3.2，复极化 在持续的心室心动过速之前的变化；和 项目3.3，复极化变化是ESVEM结果的预测指标 审判。 这三个副投影是通过一般假设统一的： 复极化的变化之前，可能是心室的原因 心律失常。 在项目3.1中，我们将检查复极的性质和程度 QT反映的急性心肌梗塞期间的变化 间隔，激活回收间隔和QRST积分。 我们 将确定静止电位的变化的程度 负责更改QRST积分。 录制系统 人类长期变化的重度变化将得到验证。 在项目3.2中，我们将测量发生的复极化变化 在患者的持续心室心动过速发作之前 使用Holter Tape的自动分析参加了ESVEM试验 录音。 在项目3.3中，我们将使用相同的能力和患者群体 评估复极变异性的预后意义 持续时间以及该变异性变化之间的关系。