ADOLESCENT ALCOHOL ABUSE--BIOBEHAVIORAL MANIFESTATIONS

青少年酗酒——生物行为表现

• 批准号: 2000250
• 负责人: Samuel Gershon
• 金额: $ 148.65万
• 依托单位: UNIVERSITY OF PITTSBURGH AT PITTSBURGH
• 依托单位国家: 美国
• 财政年份: 1990
• 资助国家: 美国
• 起止时间: 1990-09-28 至 2000-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2000250
• 关键词: adolescence (12-20); alcoholism /alcohol abuse; clinical research; human subject

This application is submitted in response to RFA AA-94-08 for renewal of support for the Pittsburgh Adolescent Alcohol Research Center (PAARC), located within the Department of Psychiatry of the University of Pittsburgh School of Medicine. PAARC is the only alcohol research center supported by the National Institute on Alcohol Abuse and Alcoholism that focuses on diagnosed alcohol abuse and dependence among adolescents aged 12 through 18 hears of age. The overarching goal of the Pittsburgh Adolescent Alcohol Research Center is to enhance understanding of the structure, development, and consequences of adolescent alcohol use disorders through cross-sectional and longitudinal investigations of clinical and community samples of adolescents (N=500). Specific goals of the projects for the next 5-year period are to: (1) Develop a new and more appropriate adolescent taxonomy of alcohol use disorders/ (2) Determine the impact of alcohol use disorders on the developmental transitions during adolescence and young adulthood; (3) Elucidate brain-behavior covariation among impulsive/aggressive alcohol abusing or dependent adolescents; (4) Clarify the psychobiological mechanisms pertaining to stress and trauma that may underlie the linkage between PTSD and adolescent alcohol use disorders; and, (5) Identify the precipitants of lapse and relapse in adolescents. Excessive alcohol consumption and its consequences comprise a prevalent and serious public health problem among American adolescents. our finding thus far reflect far greater clinical heterogeneity and severity than has been commonly assumed in this population. Furthermore, and most importantly, the biomedical and psychosocial findings from our comprehensive database emphasize that adolescents exhibiting alcohol use disorders cannot be assumed to be merely younger versions of adult alcoholics. The enhancement of understanding of the particular nature of alcohol problems in adolescence is a necessary prerequisite to the development of effective prevention and treatment methodologies for this population.

本申请是为了响应 RFA AA-94-08 的更新而提交的 支持匹兹堡青少年酒精研究中心（PAARC）， 位于匹兹堡大学精神病学系内 医学院。 PAARC 是唯一一家由以下机构支持的酒精研究中心 国家酒精滥用和酒精中毒研究所，重点关注 12 至 18 岁青少年中诊断出的酒精滥用和依赖 听说年龄。 匹兹堡青少年酒精研究中心的总体目标 是为了加强对结构、发展和后果的理解 通过横断面和 临床和社区样本的纵向调查 青少年 (N=500)。 未来5年项目的具体目标 阶段的目标是： (1) 制定新的、更合适的青少年分类法 酒精使用障碍的发生率/ (2) 确定酒精使用的影响 青春期和青年期发育转变障碍 成年期； (3) 阐明大脑行为的协变 冲动/攻击性的酗酒或依赖青少年； (4) 阐明与压力和创伤有关的心理生物学机制 这可能是创伤后应激障碍和青少年饮酒之间联系的基础 疾病； (5) 识别失效和复发的诱因 青少年。 过量饮酒及其后果包括普遍存在的和 美国青少年面临严重的公共卫生问题。 我们的发现因此 远远反映出比以往更大的临床异质性和严重性 在这个人群中普遍假设。 此外，也是最重要的是， 我们综合数据库中的生物医学和心理社会发现 强调患有酒精使用障碍的青少年不能 被认为只是成年酗酒者的年轻版本。 增强对酒精特殊性质的了解 青春期问题是发展的必要条件 针对这一人群的有效预防和治疗方法。