Tracking relevant nanomaterial transformations, exposure, uptake and effects in freshwater and soil systems

跟踪淡水和土壤系统中相关纳米材料的转化、暴露、吸收和影响

基本信息

  • 批准号:
    NE/N006178/1
  • 负责人:
  • 金额:
    $ 42.79万
  • 依托单位:
  • 依托单位国家:
    英国
  • 项目类别:
    Research Grant
  • 财政年份:
    2015
  • 资助国家:
    英国
  • 起止时间:
    2015 至 无数据
  • 项目状态:
    已结题

项目摘要

Nanomaterials (NM) are very small particles much less than the width of a human hair. They are synthesised to provide different properties from larger forms of the same material and they are now used in a wide range of products. The properties that NMs provide include enhanced strength, an ability to reflect light or to react with other chemicals, and efficient electrical conductance. The value of NM is now very widely recognised and many companies are starting to use them in common consumer products, such as sunscreens and cosmetics, plus industry products, such as fabrics and building materials. This means that small quantities of NMs will reach the wider environment from everyday product use.A great deal of recent research has gone into assessing the safety of NMs for humans and the environment. Most of these studies have looked at NMs in their newly-manufactured forms. It is increasingly apparent, however, that once NMs are released into the wider environment, they do not stay in their manufactured state - they change or 'transform'. Transformations can affect NM size, charge, their surface coatings and their ability to bind to other things such as soil particles or other chemicals. Transformations occur both during transfer to the environment (e.g. via sewage works) and once NMs reach the wider environment itself (rivers, sediments and soils). It is of huge importance that we understand the transformation processes and environmental fate(s) of NMs as they can affect their toxicity to humans and the environment. The aim of this project is to study these NM transformations in more detail. We want to better understand whether different types of NMs are transformed in the same or different ways. We will conduct our work with different types of NMs, including those made from silver, titanium dioxide, polystyrene (a type of plastic) and graphene (a type of carbon). We will first use laboratory methods that mimic the ways that NMs are changed during sewage treatment and in natural waters and soils to create the transformed materials that we will then study. We will test how these new and changed NMs affect a range of common aquatic and soil organisms and contrasting their toxicity in their "pristine" state with that after they have been transformed in the environment for different times. During our tests, we will measure how much of each material is taken up by the organisms into different tissues and whether this affects how they grow and reproduce. We will also measure the activity of different genes that are likely to be affected as organisms take up different NMs. We predict that each NM will be transformed in a way that changes its likelihood to cause harmful effects. Each test will be repeated using different soils and waters typically found across the UK, to determine how transformations vary under different conditions.Finally, we will build custom-made, large exposure systems ('mesocosms') designed to mimic the rivers into which sewage works discharged and soils upon which sludge is spread, and populate them with a wide range of common UK native plants, invertebrates and fish (in the waters). By following these mesocosms for several months, we can simulate what may actually be happening in real UK environments in terms of the fate and effects of our transformed NMs. We will use the results to improve models able to predict how our transformed NMs will behave and the effects they will have. Taken together, our results should help us to predict the toxicity of NMs to help assure their safety, supporting the growth of the nanotechnology industry into the future. To this latter end we will run and coordinate a UK Nano-Academics & Regulators Platform, and will also present our results through major European Union (NanoSafety Cluster) and worldwide (Organisation for Economic Cooperation and Discussion) policy working groups, as well as to the public, so reaching as wide an audience as possible.
纳米材料(NM)比人头发的宽度小得多。它们合成以提供来自较大形式的相同材料的不同性质,现在它们被用于广泛的产品。 NMS提供的特性包括增强的强度,反射光或与其他化学物质反应的能力以及有效的电导。现在,NM的价值已被广泛认可,许多公司开始将其用于常见的消费产品,例如防晒和化妆品,以及工业产品,例如面料和建筑材料。这意味着少量NM将从日常产品使用中到达更广泛的环境。最近的大量研究已用于评估NMS对人类和环境的安全。这些研究中的大多数都研究了其新制造形式的NMS。但是,越来越明显的是,一旦NM释放到更广泛的环境中,它们就不会保持在制造状态 - 它们会改变或“变换”。转换会影响NM的大小,电荷,其表面涂层以及它们与其他物质(例如土壤颗粒或其他化学物质)结合的能力。转变在转移到环境期间(例如,通过污水处理)以及NMS到达更广泛的环境本身(河流,沉积物和土壤)。我们了解NMS的转型过程和环境命运是非常重要的,因为它们可以影响其对人类和环境的毒性。该项目的目的是更详细地研究这些NM转换。我们希望更好地理解不同类型的NMS是以相同或不同的方式转换。我们将使用不同类型的NM进行工作,包括由银,二氧化钛,聚苯乙烯(一种塑料)和石墨烯(一种碳)制成的。我们将首先使用实验室方法,这些方法模仿污水处理过程中NMS以及在天然水域和土壤中改变的方式来创建转化的材料,然后我们将研究这些材料。我们将测试这些新的和改变的NM如何影响一系列常见的水生生物,并将其在“原始”状态的毒性与它们在不同时期发生在环境中发生后的毒性与之对比。在测试期间,我们将测量每种材料被生物体吸收到不同组织中,以及这是否影响它们的生长和繁殖方式。我们还将衡量随着生物占用不同的NM的不同基因的活性,这些基因可能受到影响。我们预测,每个NM将以改变其可能引起有害影响的可能性的方式进行转换。每次测试将使用通常在英国各地发现的不同土壤和水域重复,以确定在不同条件下变化的变化。在本文中,我们将建立定制的大型暴露系统(“ Mesocosms”),该系统旨在模仿污水中的河流。排放的作品和污泥散布的土壤,并用各种普通的英国本地植物,无脊椎动物和鱼(在水域中)填充它们。通过遵循这些中兆几个月的时间,我们可以根据我们转型的NMS的命运和影响来模拟在真正的英国环境中实际发生的事情。我们将使用结果来改进能够预测我们转化的NM的行为以及它们将产生的影响的模型。综上所述,我们的结果应有助于我们预测NMS的毒性,以确保其安全性,并支持纳米技术行业在未来中的增长。为了后,我们将运行并协调英国纳米纳米学院和监管机构平台,还将通过主要的欧盟(纳米安全集群)和全球(经济合作与讨论组织)政策工作组以及有关工作组以及有关的欧洲联盟(Nanosafety Cluster)以及有关我们的成果。公众,尽可能广泛地吸引观众。

项目成果

期刊论文数量(10)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Mitigating effect of organic matter on the in vivo toxicity of metal oxide nanoparticles in the marine environment
  • DOI:
    10.1039/c8en00175h
  • 发表时间:
    2018-07
  • 期刊:
  • 影响因子:
    0
  • 作者:
    Seta Noventa;D. Rowe;T. Galloway
  • 通讯作者:
    Seta Noventa;D. Rowe;T. Galloway
Microplastics in marine mammals stranded around the British coast: ubiquitous but transitory?
  • DOI:
    10.1038/s41598-018-37428-3
  • 发表时间:
    2019-01-31
  • 期刊:
  • 影响因子:
    4.6
  • 作者:
    Nelms, S. E.;Barnett, J.;Godley, B. J.
  • 通讯作者:
    Godley, B. J.
Gold nanoparticles ingested by oyster larvae are internalized by cells through an alimentary endocytic pathway
  • DOI:
    10.1080/17435390.2018.1487601
  • 发表时间:
    2018-07
  • 期刊:
  • 影响因子:
    5
  • 作者:
    Seta Noventa;Christian Hacker;Ana Correia;Claudia Drago;T. Galloway
  • 通讯作者:
    Seta Noventa;Christian Hacker;Ana Correia;Claudia Drago;T. Galloway
An engaged research study to assess the effect of a 'real-world' dietary intervention on urinary bisphenol A (BPA) levels in teenagers.
  • DOI:
    10.1136/bmjopen-2017-018742
  • 发表时间:
    2018-02-03
  • 期刊:
  • 影响因子:
    2.9
  • 作者:
    Galloway TS;Baglin N;Lee BP;Kocur AL;Shepherd MH;Steele AM;BPA Schools Study Consortium;Harries LW
  • 通讯作者:
    Harries LW
Plastics and the Environment
塑料与环境
  • DOI:
    10.1039/9781788013314-00131
  • 发表时间:
    2018
  • 期刊:
  • 影响因子:
    0
  • 作者:
    Galloway T
  • 通讯作者:
    Galloway T
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Tamara Susan Galloway其他文献

Tamara Susan Galloway的其他文献

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{{ truncateString('Tamara Susan Galloway', 18)}}的其他基金

Future Fibres Networking Grant
未来光纤网络补助金
  • 批准号:
    NE/Y003985/1
  • 财政年份:
    2023
  • 资助金额:
    $ 42.79万
  • 项目类别:
    Research Grant
Reducing the impacts of plastic waste in the Eastern Pacific Ocean
减少东太平洋塑料废物的影响
  • 批准号:
    NE/V005448/1
  • 财政年份:
    2021
  • 资助金额:
    $ 42.79万
  • 项目类别:
    Research Grant
Current and Future Effects of Microplastics on Marine Shelf Ecosystems (MINIMISE)
微塑料对海洋陆架生态系统当前和未来的影响(MINIMISE)
  • 批准号:
    NE/S003975/1
  • 财政年份:
    2019
  • 资助金额:
    $ 42.79万
  • 项目类别:
    Research Grant
Bioavailability and biological effects of microscopic plastic debris in the ocean
海洋中微小塑料碎片的生物利用度和生物效应
  • 批准号:
    NE/L007010/1
  • 财政年份:
    2014
  • 资助金额:
    $ 42.79万
  • 项目类别:
    Research Grant
PROSPEcT: Ecotoxicology test protocols for representative nanomaterials in support of the OECD sponsorship programme
前景:支持经合组织赞助计划的代表性纳米材料的生态毒理学测试方案
  • 批准号:
    EP/G043140/1
  • 财政年份:
    2009
  • 资助金额:
    $ 42.79万
  • 项目类别:
    Research Grant

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相似海外基金

Tracking relevant nanomaterial transformations, exposure, uptake and effects in freshwater and soil systems
跟踪淡水和土壤系统中相关纳米材料的转化、暴露、吸收和影响
  • 批准号:
    NE/N006569/1
  • 财政年份:
    2015
  • 资助金额:
    $ 42.79万
  • 项目类别:
    Research Grant
Tracking relevant nanomaterial transformations, exposure, uptake and effects in freshwater and soil systems
跟踪淡水和土壤系统中相关纳米材料的转化、暴露、吸收和影响
  • 批准号:
    NE/N006224/1
  • 财政年份:
    2015
  • 资助金额:
    $ 42.79万
  • 项目类别:
    Research Grant
Project 1: Mechanisms of Nanomaterial-Cell Interactions
项目1:纳米材料-细胞相互作用机制
  • 批准号:
    8067694
  • 财政年份:
    2010
  • 资助金额:
    $ 42.79万
  • 项目类别:
Project 1: Mechanisms of Nanomaterial-Cell Interactions
项目1:纳米材料-细胞相互作用机制
  • 批准号:
    8274447
  • 财政年份:
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    $ 42.79万
  • 项目类别:
Project 1: Mechanisms of Nanomaterial-Cell Interactions
项目1:纳米材料-细胞相互作用机制
  • 批准号:
    8675241
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    $ 42.79万
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