DEVELOPMENT AND MAINTENANCE OF AN ANIMAL BREED

动物品种的开发和维持

• 批准号: 2658287
• 负责人: STEPHEN L PEARSON
• 金额: $ 48.13万
• 依托单位: COVANCE RESEARCH PRODUCTS, INC.
• 依托单位国家: 美国
• 财政年份: 1988
• 资助国家: 美国
• 起止时间: 1988-09-30 至 1998-09-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2658287
• 关键词: AIDS; Betaherpesvirinae; Cercopithecid herpesvirus 1; Macaca mulatta; Retroviridae; animal breeding; animal care; animal colony; enzyme linked immunosorbent assay; germ free condition; health science research; serotyping; simian immunodeficiency virus; simian virus

The overall objective of this program is to maintain and expand on existing breeding colony of SPF (Herpes B Virus, SIV, SRV and STLV1) rhesus monkeys. The offspring from this colony will be available to the scientific community for use in biomedical research with priority given to NIH sponsored AIDS related studies. Specific Aim: 1 Main the SPF status of the colony by submission of samples to NIH approved laboratories at intervals of six months or less. Specific Aim: 2 Expand the breeding colony by retention of selected offspring. Specific Aim: 3 Initiate a pilot program to determine the feasibility of eliminating Simian Foamy Virus infection from all or a subunit of the colony. The colony should provide 125-150 eighteen month old animals for research each year. The utilization of these animals would essentially eliminate the danger of Herpes B Virus transmission from the monkey to research personnel and provide a dependable source of simian retrovirus free animals for critical AIDS related research.

该计划的总体目标是维持和扩展 SPF（疱疹 B 病毒、SIV、SRV 和 STLV1）的现有繁殖群 恒河猴。 该殖民地的后代将可供 科学界优先用于生物医学研究 NIH 资助的艾滋病相关研究。 具体目标： 1 注重SPF 通过向 NIH 提交样品来了解菌落状态并获得批准 实验室间隔六个月或更短时间。 具体目标：2 展开 通过保留选定的后代来繁殖群体。 具体目标： 3 启动试点计划以确定消除的可行性 猿猴泡沫病毒感染来自整个群体或一个亚单位的群体。 该群体应提供 125-150 只 18 个月大的动物用于研究 每年。 对这些动物的利用将基本上消除 B型疱疹病毒从猴子传播给研究的危险 人员并提供可靠的免费猿猴逆转录病毒来源 用于关键艾滋病相关研究的动物。