DEVELOPMENT AND MAINTENANCE OF AN ANIMAL BREED

动物品种的开发和维持

• 批准号: 2282997
• 负责人: STEPHEN L PEARSON
• 金额: $ 53.44万
• 依托单位: COVANCE RESEARCH PRODUCTS, INC.
• 依托单位国家: 美国
• 财政年份: 1988
• 资助国家: 美国
• 起止时间: 1988-09-30 至 1997-09-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2282997
• 关键词: AIDS; Betaherpesvirinae; Cercopithecid herpesvirus 1; Macaca mulatta; Retroviridae; animal breeding; animal care; animal colony; enzyme linked immunosorbent assay; germ free condition; health science research; serotyping; simian immunodeficiency virus; simian virus

The overall objective of this program is to maintain and expand on existing breeding colony of SPF (Herpes B Virus, SIV, SRV and STLV1) rhesus monkeys. The offspring from this colony will be available to the scientific community for use in biomedical research with priority given to NIH sponsored AIDS related studies. Specific Aim: 1 Main the SPF status of the colony by submission of samples to NIH approved laboratories at intervals of six months or less. Specific Aim: 2 Expand the breeding colony by retention of selected offspring. Specific Aim: 3 Initiate a pilot program to determine the feasibility of eliminating Simian Foamy Virus infection from all or a subunit of the colony. The colony should provide 125-150 eighteen month old animals for research each year. The utilization of these animals would essentially eliminate the danger of Herpes B Virus transmission from the monkey to research personnel and provide a dependable source of simian retrovirus free animals for critical AIDS related research.

该计划的总体目标是维护和扩展 现有的SPF繁殖菌落（疱疹病毒，SIV，SRV和STLV1） 恒河猴。 这个殖民地的后代将提供给 优先级用于生物医学研究的科学界 NIH赞助的艾滋病相关研究。 特定目的：1主SPF 通过向NIH批准提交样品的殖民地状态 实验室的间隔六个月或更短。 特定目的：2扩展 通过保留选定后代的繁殖菌落。 具体目的： 3启动试点计划以确定消除的可行性 来自菌落的全部或亚基的猿猴泡沫病毒感染。 殖民地应提供125-150个18个月大的动物进行研究 每年。 这些动物的利用本质上可以消除 疱疹B病毒从猴子传播到研究的危险 人员并提供可靠的替代性逆转录病毒的可靠来源 与关键艾滋病相关研究的动物。