MOLECULAR ANALYSIS OF GENE REGULATION AND PROLIFERATIVE CONTROL IN HUMAN CELLS

人类细胞基因调控和增殖控制的分子分析

• 批准号: 4692430
• 负责人: B I GERWIN
• 金额: --
• 依托单位: DIVISION OF CANCER EPIDEMIOLOGY AND GENETICS
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/4692430
• 关键词: asbestos; benzanthracenes; carcinogenesis; carcinoma; chemical carcinogenesis; environmental toxicology; gene expression; gene mutation; genetic manipulation; genetic mapping; genetic recombination; hepatitis B virus group; human tissue; lung; lung neoplasms; mesothelioma; molecular oncology; neoplasm /cancer genetics; nucleic acid sequence; nucleocapsid; respiratory epithelium; viral carcinogenesis; virus antigen; virus genetics

The goal of this new project is to understand the molecular controls of mitogenesis and terminal differentiation of human lung cells. Preliminary results suggest the mesothelioma cells may escape regulatory controls by producing their own mitogen. A study has been initiated to identify critical steps in the terminal differentiation of human bronchial epithelial cells.

这个新项目的目标是了解分子控制 人肺细胞的有丝分裂和终末分化。 初步的 结果表明间皮瘤细胞可能通过以下方式逃避监管控制 产生自己的有丝分裂原。 一项研究已经启动，以确定 人支气管终末分化的关键步骤 上皮细胞。