TOPOLOGICAL CHARACTERIZATION OF OPIATE RECEPTORS

阿片受体的拓扑特征

• 批准号: 4689170
• 负责人: K C RICE
• 金额: --
• 依托单位: NAT INST OF ARTHRITIS, DIABETES, DIGESTIVE & KIDNEY DISEASES
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/4689170
• 关键词: analgesics; chemical binding; chemical structure function; conformation; drug design /synthesis /production; morphine; narcotics; opiate alkaloid

Exploratory synthetic studies aimed at route selection for synthesis of the three conformationally restricted 5-m-hydroxyphenylmorphans remaining in this series as topological probes for opiate receptor subpopulation specificity have been carried out. Results of these studies indicate potentially feasible routes have been identified.

探索性合成研究旨在选择合成路线 三个构象限制的 5-m-羟基苯基吗喃保留在 该系列作为阿片受体亚群的拓扑探针 并进行了针对性的处理。 这些研究结果表明 已经确定了潜在可行的路线。