PSYCHOBIOLOGICAL ALTERATIONS IN AGING COMBAT VETERANS W/ PTSD

患有创伤后应激障碍 (PTSD) 的老年退伍军人的心理生物学变化

• 批准号: 6264355
• 负责人: RACHEL YEHUDA
• 金额: $ 4.76万
• 依托单位: MOUNT SINAI SCHOOL OF MEDICINE OF CUNY
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-12-01 至 1999-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6264355
• 关键词: 3 methoxy 4 hydroxyphenylethyleneglycol; adrenocorticotropic hormone; aging; bioperiodicity; circadian rhythms; clinical research; corticosteroid receptors; cortisol; human old age (65+); human subject; hypothalamic pituitary adrenal axis; lymphocyte; metyrapone; posttraumatic stress disorder; psychobiology; veterans

This protocol will attempt to (1) evaluate feedback inhibition of the HPA axis in elderly combat veterans and controls; (2) assess suprapituitary activation of the HPA axis using the metyrapone stimulation test; (3) characterize lymphocyte glucocorticoid receptor activity as a measure of the dynamics of the HPA axis; and (4) charctarize the circadian rhythm of cortisol, ACTH, NE, and MHPG using chronobiological techniques.

该方案将尝试（1）评估老年战斗人员和对照组中HPA轴的反馈抑制； （2）使用Metyrapone刺激测试评估HPA轴的超拟合激活； （3）将淋巴细胞糖皮质激素受体活性表征为HPA轴动力学的量度； （4）使用时间生物学技术来绕皮质醇，ACTH，NE和MHPG的昼夜节律。