THALAMO CORTICAL PATHWAYS IN "BLINDSIGHT"

“盲视”中的丘脑皮质通路

• 批准号: 6288150
• 负责人: HILLARY R RODMAN
• 金额: $ 8.51万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-05-01 至 2000-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6288150
• 关键词: Mammalia; animal tissue; behavioral /social science research tag; cognition; growth /development; injury; nervous system; psychology

Humans with damage to primary visual cortex (V1) are for most purposes blind, although in some circumstances they can "guess" accurately about stimuli they do not consciously see (blindsight); if the damage occurs early in life recovery can be very good and include some awareness of stimuli and ability to discriminate direction of motion. This project assesses the role of cells in the visual thalamus in the improved recovery via a monkey model of neurophysiological and anatomical changes. This year, additional subjects with V1 damage were prepared for single-unit recording and anatomical studies. In addition, using anatomical techniques in normal subjects, we found a clear absence of a transient pathway between the geniculate and cortical areas involved in visual motion processing early in life, a pathway which is present in the cat and which contributes to recovery of vision after cortical damage in that species. This result rules out one possibility for the ne ural basis of the improved recovery, and argues against the assumption that visual mechanisms are similar in detail in other mammals and monkeys. Clearly, monkeys are required to draw insights about primate nervous systems. FUNDING NSF IBN-9723178 $45,960 9/01/97 - 8/31/00 PUBLICATIONS Moore, T., Rodman, H.R. and Gross, C.G. Man, monkey and blindsight. The Neuroscientist 4:227-230, 1998.

对主要视觉皮层损害（V1）损害的人类大多数 目的是盲目的，尽管在某些情况下他们可以“猜测” 准确地谈论他们没有有意识地看到的刺激（盲目）；如果 损害发生在生命的早期可能非常好，包括 对刺激的某些意识和区分方向的能力 运动。 该项目评估细胞在视觉中的作用 丘脑通过猴子模型改善了恢复 神经生理和解剖学变化。 今年，额外 为单单元记录准备了具有V1损坏的受试者 解剖学研究。 另外，使用解剖技术 正常受试者，我们发现明显没有瞬态途径 在视觉运动中涉及的晶状体和皮质区域之间 生命的早期处理，这是一条猫中存在的途径 这有助于皮质损伤后的视力恢复 物种。 该结果排除了新的可能性 改善恢复，并反对以下假设 在其他哺乳动物和猴子中，视觉机制的详细信息相似。 显然，需要猴子吸引有关灵长类动物的见解 系统。 资金NSF IBN -9723178 $ 45,960 9/01/97-8/31/00 出版物Moore，T.，Rodman，H.R。和Gross，C.G。伙计，猴子和 盲目。 神经科学家4：227-230，1998。