CORRECTION OF NEONATAL MONOCULAR APHAKIA W/ IOLS

人工晶状体矫正新生儿单眼无晶状体

• 批准号: 6288147
• 负责人: SCOTT R LAMBERT
• 金额: $ 8.51万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-05-01 至 2000-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6288147
• 关键词: Mammalia; behavioral /social science research tag; congenital disorders; eye; growth /development; nervous system; psychology; vision; Mammalia; behavioral /social science research tag; congenital disorders; eye; growth /development; nervous system; psychology; vision

The overall goal of this project is to understand the molecular basis of eye growth during infancy using a monkey model. In particular, we are interested in the effect of aphakia on ocular growth and the factors that mediate these changes. Understanding the mechanism whereby aphakia alters ocular growth is important for the following reasons. First, it should make it possible to more accurately select the most appropriate intraocular lens power to implant into infantile eyes after cataract surgery. In addition by understanding the mechanisms retarding ocular growth, it may be possible to modulate the excessive ocular growth that occurs on certain pathological conditions such as retinopathy of prematurity. FUNDING NIH EY08544 $149,368 9/30/93 - 1/31/99 PUBLICATIONS Lambert, S.R. The effect of age on the retardation of axial elongation following a lensectomy in infant monkeys. Arch. Ophthalmol. 116:781-784, 1998. Lambert S.R. Ocular growth in early childhood Implications for pediatric cataract surgery. Operative Techniques in Cataract and Refractive Surgery 1:159-164, 1998. P51RR00165-38 1/1/98 - 12/31/98 Yerkes Regional Primate Research Center

该项目的总体目标是了解分子 使用猴子模型在婴儿期生长的基础。 在 特别是，我们对阿法基亚对眼的影响感兴趣 增长和介导这些变化的因素。 了解 Aphakia会改变眼的生长的机制对 以下原因。 首先，应该使更多 准确选择最合适的眼内镜头功率 白内障手术后植入婴儿眼。 另外 了解延迟眼增长的机制，可能是 可能调节发生在 某些病理状况，例如早产性视网膜病变。 资金NIH EY08544 $ 149,368 9/30/93-1/31/99 Publications Lambert， S.R.年龄对轴向伸长延伸的影响 在婴儿猴子进行晶状体切除术后。 拱。 眼科。 116：781-784，1998。Lambert S.R.幼儿时代的眼部增长 对小儿白内障手术的影响。 手术技术 白内障和屈光手术1：159-164，1998。P51RR00165-38 1/1/98 -12/31/98 Yerkes地区灵长类动物研究中心