BIOAVAILABILITY, DISSOLUTION, SORPTION, AND NOXICITY OF NAPL

NAPL 的生物利用度、溶解、吸附和毒性

• 批准号: 6296556
• 负责人: WALTER J WEBER
• 金额: $ 15.1万
• 依托单位: MICHIGAN STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-04-01 至 2000-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6296556
• 关键词: adsorption; biotransformation; carbopolycyclic compound; chemical kinetics; environmental contamination; environmental engineering; environmental protection; environmental transport; ground water; hydropathy; mathematical model; model design /development; nonwater solvent; phase change; solutions

Nonaqueous phase organic liquids are widespread contaminants of subsurface soils and groundwater. From a human health perspective, these organic liquids are of particular concern because they tend to represent long-term sources of pollution and create diverse and persistent pathways for eventual human exposure. The work proposed in this Project is directed towards the investigation of processes which influence the entrapment, persistence, transport, bioavailability, and toxicity of organic liquid components in the natural subsurface environment. It represents a fundamental research program which builds upon previous and current NIEHS-funded projects and integrates laboratory and mathematical modeling investigations. This project focuses on the behavior and toxicity of complex polycyclic aromatic hydrocarbon (PAH) mixtures. Its specific aims relate to the quantification of compositional influences on phase equilibria, mass transfer kinetics, and biotransformations, and to the exploration of sorption processes and bioavailability in natural media. Collaboration with other project investigators through the Products Evaluation Core will facilitate the assessment of the epigenetic toxicity of PAH mixture prior and subsequent to biotransformation. Thus, the work proposed is designed to logically extend the knowledge gained in previous NIEHS-funded projects to consider the interaction of multiple processes, the influence of chemical and physical heterogeneities on these processes, and the behavior and fate of complex NAPL mixtures. Although directed primarily at the investigation of naturally occurring attenuation processes, the knowledge gained from these studies will have immediate applications to the design of more effective remediation strategies.

非水相有机液体是广泛存在的污染物 地下土壤和地下水。 从人类健康的角度来看，这些 有机液体受到特别关注，因为它们往往代表 长期污染源并创造多样化和持久的途径 用于最终的人体暴露。 本项目建议的工作是 旨在调查影响的过程 的截留、持久性、运输、生物利用度和毒性 自然地下环境中的有机液体成分。 它 代表了一项基础研究计划，该计划建立在以前和 当前 NIEHS 资助的项目，整合了实验室和数学 建模调查。 该项目重点关注行为和 复杂多环芳烃（PAH）混合物的毒性。 它是 具体目标涉及成分影响的量化 关于相平衡、传质动力学和生物转化，以及 探索自然中的吸附过程和生物利用度 媒体。 通过以下方式与其他项目研究人员合作 产品评估核心将促进表观遗传的评估 PAH 混合物在生物转化之前和之后的毒性。 因此， 拟议的工作旨在逻辑地扩展所获得的知识 在以前的 NIEHS 资助的项目中考虑了多个相互作用 过程、化学和物理异质性的影响 这些过程，以及复杂 NAPL 混合物的行为和命运。 虽然主要针对自然发生的调查 衰减过程，从这些研究中获得的知识将具有 立即应用于更有效修复的设计 策略。