PUBERTAL CHANGES & HORMONAL INFLUENCES IN CHILDREN W/CP

青春期的变化

• 批准号: 6207585
• 负责人: CHRISTINE M HOULIHAN
• 金额: $ 4.26万
• 依托单位: UNIVERSITY OF VIRGINIA
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-02-01 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/6207585
• 关键词: adolescence (12-20); body composition; cerebral palsy; child (0-11); child physical development; clinical research; hormone regulation /control mechanism; human puberty; human subject; longitudinal human study; nutrition; nutrition related tag; obesity

The surveillance of growth and pubertal development plays an integral role in the health maintenance of all children. For children with disabilities, including cerebral palsy (CP), there is little scientific data on nutrition, growth, and maturation. This proposal's hypotheses are: a) the timing and tempo of sexual maturation in children with CP differs from the normal population, and b) nutritional and hormonal mechanisms are responsible for these differences in sexual maturation. The specific aims of the study are: 1) To determine the interactions among nutrition, adiposity, hormones, and the onset and progression of puberty in children wit moderate-severe CP; 2) To determine the changes in nutritional status, linear growth, sexual maturation, and skeletal maturation over one year in a representative sample of children with CP; and 3) To compare the onset and progression of puberty and the hormonal influences controlling these processes in children with CP to a reference group of normally growing children in a cross sectional and longitudinal matched-pairs design.

对增长和青春期发展的监视在所有儿童的健康维持中起着不可或缺的作用。 对于包括脑瘫（CP）在内的残疾儿童，关于营养，生长和成熟的科学数据很少。该提议的假设是：a）CP儿童的性成熟的时机和速度与正常人群不同，b）营养和荷尔蒙机制在性成熟方面造成了这些差异。 该研究的具体目的是：1）确定营养，肥胖，激素以及儿童的青春期中等重度CP的相互作用； 2）在代表性的CP儿童样本中，确定营养状况，线性生长，性成熟和骨骼成熟的变化； 3）要比较青春期的发作和进展以及在CP儿童中控制这些过程的荷尔蒙影响与在横截面和纵向匹配的设计中的常规儿童的参考组。