CARDIOVASCULAR RESPONSES TO PARTICULATE AIR POLLUTION

微粒空气污染的心血管反应

• 批准号: 6039433
• 负责人: Duanping Liao
• 金额: $ 17.47万
• 依托单位: PENNSYLVANIA STATE UNIV HERSHEY MED CTR
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-05-01 至 2003-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6039433
• 关键词: air pollution; autonomic nervous system; cardiovascular disorder; cardiovascular disorder epidemiology; cardiovascular function; cardiovascular pharmacology; clinical research; environmental toxicology; human data; longitudinal human study

DESCRIPTION: (Adapted from the Investigator's Abstract) The aims of this study are to evaluate the relationship between air pollution and cardiovascular diseases and specifically to evaluate parameters which may help to elucidate biologic mechanisms by which air pollution may result in cardiovascular disease. Specifically, the study will investigate the relationship between exposure to criteria air pollutants and cardiac autonomic control measured by heart rate variability, cardiovascular reactivity, markers of inflammation and the presence of arrhythmias. The project will also investigate the relationship between ambient air pollution and validated cardiovascular disease including sudden cardiac death, myocardial infarction, CHD and stroke. Air pollution data will be obtained from the US EPA and abstracted into 1, 2, 3 or 6 day mean exposure levels for the dates prior to the individual participant=s clinical exams for baseline and exam 4 of the ARIC study. The ARIC study is a biracial population-based study of cardiovascular disease in 15,792 individuals in four US communities. The baseline examination of the cohort occurred from 1987-1989, with annual recontacts and reexaminations every three years. Numerous biologic measures and health data are obtained at these visits.

描述：（根据调查员的摘要改编）这项研究的目的 正在评估空气污染与心血管之间的关系 疾病，专门用于评估可能有助于阐明的参数 空气污染可能导致心血管的生物学机制 疾病。具体而言，该研究将研究 暴露于标准空气污染物和心脏自主神经控制 心率变异性，心血管反应性，炎症的标志和 心律不齐的存在。该项目还将调查关系 在环境空气污染和经过验证的心血管疾病之间 突然心脏死亡，心肌梗塞，CHD和中风。空气污染数据 将从美国EPA获得，并将其抽象为1、2、3或6天平均 个人参与者之前的日期暴露水平= S临床 ARIC研究的基线和考试4的考试。 ARIC研究是混血儿 基于人群的心血管疾病研究中有15,792个人 美国社区。队列的基线检查发生在1987 - 1989年， 每三年每年进行一次重新接触和重新检查。许多生物学 在这些访问中获得措施和健康数据。