Towards a systematic understanding of aerobic methylated amine metabolism in the ocean

系统地了解海洋中有氧甲基化胺代谢

• 批准号: NE/H016236/1
• 负责人: Yin Chen
• 金额: $ 40.09万
• 依托单位: University of Warwick
• 依托单位国家: 英国
• 项目类别: Fellowship
• 财政年份: 2010
• 资助国家: 英国
• 起止时间: 2010 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=NE%2FH016236%2F1
• 关键词: Towards; systematic; understanding; aerobic; methylated

Methylated amine compounds (MAs) are ubiquitous in the ocean and play significant roles in marine nutrient cycling and atmospheric chemistry. MAs are involved in the formation of aerosols and neutralization of atmospheric acidity resulting from the oxidation of nitrogen- and sulfur-containing compounds. MAs also contribute to the 'greenhouse effect' by the formation of nitrous oxide (N2O) and hydrogen cyanide (HCN) from their oxidation by hydroxyl radicals and ozone, and by being precursors for methane (CH4) produced by methanogens. Despite the global importance of marine MAs, modelling and quantifying their environmental impacts has been hindered by a paucity of data on the origins and sinks of these compounds. Microorganisms are known to use MAs as sources of energy and nutrients therefore affecting the concentrations of MAs in the ocean and hence fluxes across the air-sea interface; however, the identities of these key players and metabolic pathways remain largely unknown. The objective of this proposed research is to characterize the diversity and abundance of marine MA utilizers and to investigate the enzymology and regulation of MA-metabolizing pathways using model marine microorganisms. This research will test the hypothesis that MAs are used as a carbon (C) source by specialized methylotrophs (bacteria that use one-carbon (C1) compounds) in the ocean, and that diverse marine microorganisms can metabolize MAs as a source of nitrogen (N).

甲基化胺化合物（MAS）在海洋中无处不在，在海洋营养循环和大气化学中起着重要作用。 MAS参与了气溶胶的形成以及由含氮和含硫化合物的氧化而导致的大气酸度中和。 MAS还通过羟基自由基和臭氧的氧化以及甲烷（CH4）的前体而形成一氧化二氮（N2O）（N2O）和氰化氢（HCN），从而有助于“温室效应”。尽管海洋MAS具有全球重要性，但对这些化合物的起源和水槽的数据很少，对它们的环境影响进行了建模和量化的环境影响。众所周知，微生物将MAS用作能量和营养的来源，因此影响了海洋中MAS的浓度，从而影响了整个空气界面的通量。但是，这些主要参与者和代谢途径的身份在很大程度上是未知的。这项拟议的研究的目的是表征海洋MA利用者的多样性和丰度，并使用模型的海洋微生物研究MA-Anetabolized途径的酶学和调节。这项研究将检验以下假设：MAS通过在海洋中使用单碳（C1）化合物的专门甲基营养物（C）用作碳（C）来源，并且多样化的海洋微生物可以将MAS代谢为氮（N）的来源。

项目成果

Handbook of Molecular Microbial Ecology I - Metagenomics and Complementary Approaches

分子微生物生态学手册 I - 宏基因组学和补充方法

• DOI: 10.1002/9781118010518.ch55
• 发表时间: 2011
• 作者: Chen Y