ARE P27 AND P21 TUMOR SUPPRESSORS

P27 和 P21 是肿瘤抑制剂

• 批准号: 6173203
• 负责人: Matthew L Fero
• 金额: $ 8.78万
• 依托单位: FRED HUTCHINSON CANCER RESEARCH CENTER
• 依托单位国家: 美国
• 财政年份: 1996
• 资助国家: 美国
• 起止时间: 1996-09-01 至 2001-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6173203
• 关键词: breast neoplasms; cell cycle; cell cycle proteins; cell growth regulation; cyclins; gene targeting; genetically modified animals; laboratory mouse; neoplasm /cancer genetics; neoplastic process; oncogenes; oncoprotein p21; oncoproteins; phenotype; skin neoplasms; tissue /cell culture; tumor suppressor genes; tumor suppressor proteins

DESCRIPTION (Applicant's Description): P27 and p21 are two recently discovered proteins which cause a G1 block to cell cycle progression in response to antimitogenic stimuli. Elimination of cell cycle checkpoints mediated by molecules such as these may contribute to cellular transformation or tumor progression. Dr. Fero, an oncologist who completed his medical training at the University of Washington and the Fred Hutchinson Cancer Research Center, has created transgenic mice in order to test these hypotheses. These mice will be studied to assess the overall phenotypic effect of p27 and p21 disruption alone and in combination. The susceptibility of these mice to the development of mammary and skin tumors, both spontaneously and following exposure to carcinogens, will then be determined. The project involves collaboration of scientists from the Basic Sciences and Public Health divisions of the Hutchinson Center with scientists at the Hematology and Biochemistry divisions of the University of Washington. Dr. Fero will enhance his basic science background further by combining molecular genetics and biostatistics coursework to his research program. His goals are to develop transgenic animal models which help to unravel the mysteries of cell cycle regulation and will contribute to the development of new classes of cancer therapeutic agents.

描述（申请人的描述）：P27和P21最近是两个 发现的蛋白质会导致G1块在细胞周期中进展 对抗源性刺激的反应。 消除细胞周期检查点 通过这样的分子介导的可能有助于细胞 转化或肿瘤进展。 Fero博士，肿瘤学家 他在华盛顿大学和弗雷德·哈钦森大学的医学培训 癌症研究中心已经创建了转基因小鼠以测试这些小鼠 假设。 这些小鼠将进行研究以评估整体表型 p27和p21的影响单独和组合。 这 这些小鼠对乳腺和皮肤肿瘤发育的敏感性， 无论是自发的还是在接触致癌物之后，都将是 决定。 该项目涉及基本科学家的合作 哈钦森中心的科学和公共卫生部门 大学血液学和生物化学分裂的科学家 华盛顿。 Fero博士将通过 将分子遗传学和生物统计学课程与他的研究相结合 程序。 他的目标是开发转基因动物模型，以帮助 解开细胞周期调节的奥秘，并将有助于 开发新的癌症治疗剂。