ARE P27 AND P21 TUMOR SUPPRESSORS

P27 和 P21 是肿瘤抑制剂

基本信息

批准号：
2895592
负责人：
Matthew L Fero
金额：
$ 8.78万
依托单位：
FRED HUTCHINSON CANCER RESEARCH CENTER
依托单位国家：
美国
项目类别：
财政年份：
1996
资助国家：
美国
起止时间：
1996-09-01 至 2001-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/2895592
关键词：
breast neoplasms cell cycle cell cycle proteins cell growth regulation cyclins gene targeting genetically modified animals laboratory mouse neoplasm /cancer genetics neoplastic process oncogenes oncoprotein p21 oncoproteins phenotype skin neoplasms tissue /cell culture tumor suppressor genes tumor suppressor proteins

项目摘要

DESCRIPTION (Applicant's Description): P27 and p21 are two recently discovered proteins which cause a G1 block to cell cycle progression in response to antimitogenic stimuli. Elimination of cell cycle checkpoints mediated by molecules such as these may contribute to cellular transformation or tumor progression. Dr. Fero, an oncologist who completed his medical training at the University of Washington and the Fred Hutchinson Cancer Research Center, has created transgenic mice in order to test these hypotheses. These mice will be studied to assess the overall phenotypic effect of p27 and p21 disruption alone and in combination. The susceptibility of these mice to the development of mammary and skin tumors, both spontaneously and following exposure to carcinogens, will then be determined. The project involves collaboration of scientists from the Basic Sciences and Public Health divisions of the Hutchinson Center with scientists at the Hematology and Biochemistry divisions of the University of Washington. Dr. Fero will enhance his basic science background further by combining molecular genetics and biostatistics coursework to his research program. His goals are to develop transgenic animal models which help to unravel the mysteries of cell cycle regulation and will contribute to the development of new classes of cancer therapeutic agents.

描述（申请人的描述）：P27和p21是最近的两个发现了导致 G1 期细胞周期进程受阻的蛋白质对抗有丝分裂刺激的反应。消除细胞周期检查点由诸如此类的分子介导可能有助于细胞转化或肿瘤进展。 Fero 博士，一位肿瘤学家，完成了他在华盛顿大学和 Fred Hutchinson 医院接受过医学培训癌症研究中心创造了转基因小鼠来测试这些假设。将研究这些小鼠以评估整体表型 p27 和 p21 单独破坏和联合破坏的影响。这这些小鼠对乳腺和皮肤肿瘤的易感性，无论是自发的还是接触致癌物后，都会决定。该项目涉及基础研究中心科学家的合作哈钦森中心的科学和公共卫生部门英国大学血液学和生物化学系的科学家华盛顿。 Fero 博士将通过以下方式进一步增强他的基础科学背景：将分子遗传学和生物统计学课程结合到他的研究中程序。他的目标是开发转基因动物模型，帮助揭开细胞周期调控的奥秘，将有助于开发新型癌症治疗剂。