LYME DISEASE RISK: ROLES OF HOST DISPERSAL AND DIVERSITY

莱姆病风险：宿主扩散和多样性的作用

• 批准号: 6170214
• 负责人: Richard Simon Ostfeld
• 金额: $ 8万
• 依托单位: INSTITUTE OF ECOSYSTEM STUDIES
• 依托单位国家: 美国
• 财政年份: 1996
• 资助国家: 美国
• 起止时间: 1996-08-15 至 2003-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6170214
• 关键词: Aves; Borrelia; Ixodes; Lyme disease; Peromyscus; Ungulate; angiosperms; animal ecology; animal population density; arthropod borne communicable disease; disease outbreaks; disease reservoirs; epizootiology; field study; fluorescence microscopy; food chain; host organism interaction; human ecology; polymerase chain reaction; public health; rural area; statistics /biometry; vole

DESCRIPTION (Adapted from the Applicant's Abstract): Lyme disease remains a significant public health problem in the United States and prevention involves exposure reduction and the use of newly developed vaccines. The goal of this study is to develop methods to better anticipate where and when infected ticks are likely to be most abundant. Using seven years worth of field data gathered in southeastern New York, the authors have reported that periodic heavy production of acorn crops (masting) establishes conditions for high rates of Borrelia bugdorferi transmission among the reservoir-vector populations. The proposed research is intended to test whether: the density of infected nymphal ticks is related to earlier acorn production; that density-dependent dispersal of white-footed mice links Bb in adjoining, different habitats; that greater densities of reservoir incompetent species in maple woodlands, as opposed to oak forests result in lower levels of infections in ticks; and, that abiotic conditions in maple forests may increase the survival of immature ticks. Finally, perturbation studies of two populations of potential reservoirs will be performed to examine the effects of faunal diversity on infection prevalence.

描述（改编自申请人的摘要）：莱姆病仍然是一种 美国的重大公共卫生问题和预防包括 减少接触和使用新开发的疫苗。此举的目标 研究的目的是开发方法来更好地预测感染蜱虫的地点和时间 可能是最丰富的。使用七年收集的现场数据 在纽约州东南部，作者报告说，周期性重 橡子作物（masting）的生产为高产率创造了条件 伯氏疏螺旋体在储存媒介群体中的传播。这 拟议的研究旨在测试是否： 受感染若虫的密度 蜱虫与早期橡子生产有关；密度相关的扩散 白足鼠的 Bb 与相邻的不同栖息地相连；那个更大的 枫树林中水库无能力物种的密度，而不是 橡树林可以降低蜱虫感染的水平；并且，那个非生物 枫林中的条件可能会增加未成熟蜱虫的存活率。 最后，对两个潜在储库群体的扰动研究将 进行检查动物多样性对感染的影响 流行率。