LYME DISEASE RISK: ROLES OF HOST DISPERSAL AND DIVERSITY

莱姆病风险：宿主扩散和多样性的作用

• 批准号: 2898812
• 负责人: Richard Simon Ostfeld
• 金额: $ 8.97万
• 依托单位: INSTITUTE OF ECOSYSTEM STUDIES
• 依托单位国家: 美国
• 财政年份: 1996
• 资助国家: 美国
• 起止时间: 1996-08-15 至 2003-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2898812
• 关键词: Aves; Borrelia; Ixodes; Lyme disease; Peromyscus; Ungulate; angiosperms; animal ecology; animal population density; arthropod borne communicable disease; disease outbreaks; disease reservoirs; epizootiology; field study; fluorescence microscopy; food chain; host organism interaction; human ecology; polymerase chain reaction; public health; rural area; statistics /biometry; vole

DESCRIPTION (Adapted from the Applicant's Abstract): Lyme disease remains a significant public health problem in the United States and prevention involves exposure reduction and the use of newly developed vaccines. The goal of this study is to develop methods to better anticipate where and when infected ticks are likely to be most abundant. Using seven years worth of field data gathered in southeastern New York, the authors have reported that periodic heavy production of acorn crops (masting) establishes conditions for high rates of Borrelia bugdorferi transmission among the reservoir-vector populations. The proposed research is intended to test whether: the density of infected nymphal ticks is related to earlier acorn production; that density-dependent dispersal of white-footed mice links Bb in adjoining, different habitats; that greater densities of reservoir incompetent species in maple woodlands, as opposed to oak forests result in lower levels of infections in ticks; and, that abiotic conditions in maple forests may increase the survival of immature ticks. Finally, perturbation studies of two populations of potential reservoirs will be performed to examine the effects of faunal diversity on infection prevalence.

描述（改编自申请人的摘要）：莱姆病仍然是 美国和预防的重大公共卫生问题涉及 暴露量减少和新开发的疫苗的使用。目标的目标 研究是开发方法，以更好地预测被感染的壁虱的位置和时间 可能是最丰富的。使用收集七年的现场数据 在纽约东南部，作者报道了周期性的沉重 橡子作物的生产（桅杆）建立了高率的条件 水库向量种群中的Borrelia bugdorferi传输。这 拟议的研究旨在测试是否：感染若虫的密度 壁虱与较早的橡子生产有关；密度依赖性分散 白脚小鼠的链接在毗邻的不同栖息地中；更大 枫树林中的水库密度无能的物种，而不是 橡树森林导致壁虱感染水平较低；而且，这种非生物 枫树森林中的条件可能会增加未成熟壁虱的存活。 最后，对两个潜在储层人群的扰动研究将 进行检查，以检查动物多样性对感染的影响 流行率。