INHALED ENVIRONMENTAL/OCCUPATIONAL IRRITANTS/ALLERGENS

吸入环境/职业刺激物/过敏原

• 批准号: 6483306
• 负责人: Donovan B Yeates
• 金额: $ 2.7万
• 依托单位: AMERICAN THORACIC SOCIETY
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-03-20 至 2001-09-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6483306
• 关键词: airborne allergen; cardiopulmonary disease; environmental exposure; irritation /irritant; occupational disease /disorder; travel; workshop

Epidemiological data demonstrate increases in daily morbidity and mortality associated with short-term increases in levels of particles and associated pollutants. The primary causes of death appear to be respiratory and cardiovascular incidents in persons with compromised cardiopulmonary function, with asthmatics among the higher risk groups. The mechanisms whereby the inhaled pollutants lead to the observed responses are a matter considerable current scientific speculation and regulatory concern. This three-day workshop to be held March 30 - April 2, 2000, focuses on the acute pulmonary, cardiac, vascular and systemic responses to the inhalation of environmental and occupational and indoor airborne particles and co-pollutants that give rise to compromised physiologic function that may lead to the observed increases in morbidity and mortality. Because biological amplifiers evoked by allergens and irritants share some common pathways, the inter-comparison of the mechanisms activated or modified by these two groups of agents is intended to be emphasized in the conference. At this workshop, scientists with divergent interests related to the potential cardiopulmonary and systemic sequelae of inhaled agents will bring new insight into the potential mechanisms whereby inhaled irritants and allergens may elicit the observed responses. 1. A three-day workshop will be conducted to bring scientific experts from different disciplines together to share information on the acute mechanisms potentially involved in the debilitating and life-threatening sequelae of the inhalation of allergens, particles, and co-pollutants, to form hypotheses from the newly- shared diverse information, and to reach consensus on critical current research needs. 2. On the third day, the participants will formulate and consensus statements on current knowledge and prioritize new research needs and directions. This will be developed by the discussion group leaders into a written synthesis of current knowledge and recommendations. 3. The results of the workshop will be published in two formats. The proceedings in the form of papers resulting from presentations will be peer-reviewed and published in the journal Environmental Health Perspectives. The synthesis of current knowledge and research recommendations will be published in the American Journal of Respiratory and Critical Care Medicine.

流行病学数据表明，与颗粒和相关污染物水平的短期增加相关的每日发病率和死亡率增加。死亡的主要原因似乎是患有受损的心肺功能的人的呼吸道和心血管事件，在较高的风险组中哮喘患者哮喘。吸入污染物导致观察到的反应的机制是当前相当大的科学猜测和监管问题。这个为期三天的研讨会将于2000年3月30日至4月2日举行，重点介绍急性肺，心脏，血管和全身反应，对吸入环境，职业和室内空气中的颗粒和室内颗粒和共污染物，这些颗粒和共污染物会引起损害的生理功能这可能导致观察到的发病率和死亡率增加。由于过敏原和刺激性诱发的生物学放大器具有一些共同的途径，因此在会议中旨在强调这两组代理激活或修饰的机制的相互比较。在这个研讨会上，具有不同兴趣的科学家与吸入药物的潜在心肺和全身后遗症有关，将为潜在的机制带来新的见解，吸入刺激物和过敏原可能会引起观察到的反应。 1。将进行为期三天的研讨会，以使来自不同学科的科学专家聚集在一起，以分享有关潜在地参与吸入过敏原，颗粒和共污染物的急性和威胁生命的后遗症的急性机制的信息，以形成来自新共享的多种信息的假设，并就关键当前的研究需求达成共识。 2。在第三天，参与者将根据当前知识制定和共识声明，并优先考虑新的研究需求和方向。这将由讨论小组的领导者发展为当前知识和建议的书面综合。 3。研讨会的结果将以两种格式发布。由演讲产生的论文形式的诉讼将在《环境健康》杂志上进行同行评审和发表。当前知识和研究建议的综合将发表在《美国呼吸道和重症监护医学杂志》上。