SYMPOSIUM ON BIOLOGICAL REACTIVE INTERMEDIATES

生物反应中间体研讨会

• 批准号: 6199590
• 负责人: ROBERT SNYDER
• 金额: $ 0.8万
• 依托单位: RUTGERS, THE STATE UNIV OF N.J.
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-07-01 至 2000-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6199590
• 关键词: chemical carcinogen; free radical oxygen; meeting /conference /symposium; travel

The mechanisms by which chemicals cause their toxic or carcinogenic effects frequently involve the formation of electrophiles or free radicals, including reactive oxygen species. They often covalently bind to cellular macromolecules or cause other forms of damage which may eventually lead to cell and organ toxicity or the initiation of cancer, The International Symposium on Biological Reactive Intermediates, which began in 1975 and has been presented at five year intervals since, will next assemble at the Universite Rene Descartes, in Paris on July 16-20,2000, under the local chairmanship of Prof. Patrick Dansette. The name of the symposium will be The Sixth International Symposium on Biological Reactive Intermediates and the name of the published proceedings will be: Biological Reactive Intermediates VI: Chemical and Biological Mechanisms in Susceptibility to, and Prevention of Environmental Diseases. The program has been generated by an international program committee chaired by Prof. Terrence Monks, Univ. of Texas, Austin, and will feature 72 invited presentations from the USA and Europe. Highlights of the program will include a keynote presentation by Prof. Sten Orrenius of the Karolinska Institute, Stockholm and a closing lecture by Prof. F. Peter Guengerich, Vanderbilt Univ., Nashville. US members of the international organizing committee include Prof. D.J. Jollow, Medical Univ. of South Carolina, Charleston, Prof. I.G, Sipes, Univ. of Arizona, Tucson, and R. Snyder, Rutgers Univ., Piscataway. The total cost of the meeting is estimated at $235,000, of which this proposal requests $10,000 to help support the participation of 10 US speakers at $1,000/speaker.

化学物质引起其有毒或致癌作用的机制经常涉及电力或自由基的形成，包括活性氧。它们通常与细胞大分子共同结合或造成其他形式的损害，最终可能导致细胞和器官的毒性或癌症的开始，即国际生物反应性中间体的国际研讨会，该研讨会于1975年开始，此后五年间，将于7月16--16--20-20-20 000年7月的persions pripters pripters组成。研讨会的名称将是第六次关于生物反应性中间体的国际研讨会，发表的程序的名称将是：生物反应性中间体VI：化学和生物学机制，易感性和预防环境疾病。该计划是由由大学特伦斯·僧侣教授主持的国际计划委员会的。德克萨斯州奥斯汀的著作，并将在美国和欧洲进行72次受邀演讲。该计划的亮点将包括Karolinska Institute的Sten Orrenius教授，斯德哥尔摩的Sten Orrenius教授以及纳什维尔Vanderbilt大学F. Peter Guengerich教授的闭幕演讲。国际组织委员会的美国成员包括D.J.教授JOWLOW，医疗大学。南卡罗来纳州，查尔斯顿，I.G教授，sipes，Univ。亚利桑那州图森（Tucson）和R. Snyder的罗格斯大学（Rutgers Univ。）会议的总费用估计为235,000美元，其中该提案要求10,000美元，以帮助支持10位美国发言人的参与，每位发言人$ 1,000。