MRC Centre for Neurodevelopmental Disorders

MRC 神经发育障碍中心

• 批准号: MR/W006251/1
• 负责人: Oscar Marin
• 金额: $ 243.5万
• 依托单位: King's College London
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2021
• 资助国家: 英国
• 起止时间: 2021 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=MR%2FW006251%2F1
• 关键词: MRC; Centre; Neurodevelopmental; Disorders

Neurodevelopmental disorders are a group of conditions which are caused by an alteration in the development of the nervous system. Intellectual disabilities, autism spectrum disorder and many forms of epilepsy are caused by disturbances in the typical programme of brain development. Even psychosis and related disorders, which typically emerge later in life, are thought to have a developmental origin. Developmental brain disorders often cause life-long disability and current treatments, at best, are merely palliative.Brain development is a highly orchestrated process directed by genetic information and influenced by many environmental factors. The human brain develops over two decades, a very substantial part of our life. During that time, the brain grows from a microscopic structure to a remarkable organ that enables us to interact with the physical world, communicate, learn and imagine the unknown. Alterations in this very protracted program result in neurodevelopmental disorders. Developmental brain disorders arise through a combination of genetic and environmental (non-genetic) influences. Research over the past decade has shown that genetic changes are the most important risk factor for developmental brain disorders, independently of whether they manifest early in life, such as autism spectrum disorder or only become clinically detectable in young adults, such as psychosis. Recent advances in human genetics have identified specific mutations with these disorders. Unfortunately, we still do not understand how these mutations and concomitant environmental insults cause neurodevelopmental disorders. When the Centre was established five years ago, our vision was to build a world-class Centre at King's College London with research programmes that will transform our understanding of the origin of neurodevelopmental disorders. We have created a research environment in which we are effectively dissolving some of the boundaries preventing our progress, such as the lack of interaction between basic and clinical scientists and between clinical specialists working on different but related disorders. At the core of our strategy is an innovative PhD Programme that is training a new generation of scientists with the skills to comfortably work across basic and clinical research settings and sustain collaborations across groups.The crucial limitation for the design of new medicines for neurodevelopmental disorders continues to be our insufficient understanding of the changes that occur in the brain of affected individuals. In the next five years, the main focus of our efforts will remain the exploration of the biological mechanisms underlying neurodevelopmental disorders. In the long term, we aim to translate the new knowledge into clinical advances that change the lives of affected individuals and their families, in collaboration with industrial partners, other research centres and patient associations.

神经发育障碍是一组由神经系统发育改变引起的疾病。智力障碍、自闭症谱系障碍和多种形式的癫痫都是由典型的大脑发育程序紊乱引起的。即使是通常在晚年出现的精神病和相关疾病也被认为具有发育起源。发育性脑部疾病通常会导致终身残疾，而目前的治疗充其量只是姑息治疗。大脑发育是一个由遗传信息指导并受到许多环境因素影响的高度精心策划的过程。人类大脑的发育历经二十年，是我们生活中非常重要的一部分。在此期间，大脑从一个微观结构成长为一个非凡的器官，使我们能够与物理世界互动、交流、学习和想象未知事物。这个非常漫长的程序的改变会导致神经发育障碍。发育性脑部疾病是由遗传和环境（非遗传）影响共同引起的。过去十年的研究表明，基因变化是发育性脑部疾病最重要的危险因素，无论它们是否在生命早期表现出来，例如自闭症谱系障碍，或者仅在年轻人中临床上可检测到，例如精神病。人类遗传学的最新进展已经确定了这些疾病的特定突变。不幸的是，我们仍然不明白这些突变和伴随的环境损害如何导致神经发育障碍。五年前该中心成立时，我们的愿景是在伦敦国王学院建立一个世界一流的中心，其研究项目将改变我们对神经发育障碍起源的理解。我们创造了一个研究环境，在这个环境中，我们有效地消除了一些阻碍我们进步的界限，例如基础科学家和临床科学家之间以及研究不同但相关疾病的临床专家之间缺乏互动。我们战略的核心是一个创新的博士项目，该项目正在培训新一代科学家，使其具备在基础和临床研究环境中轻松工作并维持跨群体合作的技能。针对神经发育障碍的新药物设计的关键限制仍然存在这是我们对受影响个体大脑中发生的变化了解不够。未来五年，我们的主要工作重点仍是探索神经发育障碍的生物学机制。从长远来看，我们的目标是与工业合作伙伴、其他研究中心和患者协会合作，将新知识转化为临床进展，改变受影响个人及其家人的生活。

项目成果

A deep-learning strategy to identify cell types across species from high-density extracellular recordings

一种从高密度细胞外记录中识别跨物种细胞类型的深度学习策略

• DOI: 10.1101/2024.01.30.577845
• 发表时间: 2024-01-31
• 期刊: bioRxiv
• 作者: Maxime Beau;David J. Herzfeld;Francisco Naveros;Marie E. Hemelt;Federico D’Agostino;M. Oostl;Alvaro Sánchez;Young Yoon;Michael Maibach;Stephen Kyranakis;Hannah N. Stabb;M. Gabriela;Martínez Lopera;Agoston Lajko;Marie Zedler;Shogo Ohmae;Nathan J. Hall;B. Clark;Dana Cohen;S. Lisberger;D. Kostadinov;M. Häusser;Javier F. Medina;Bonnie Bowell;Soyon Chun;Wenjuan Kong;Caroline Reuter;Margaret Conde Paredes;Stefanie Tokiyama
• 通讯作者: Stefanie Tokiyama

Schizophrenia risk proteins ZNF804A and NT5C2 interact in cortical neurons.

精神分裂症风险蛋白 ZNF804A 和 NT5C2 在皮质神经元中相互作用。

• DOI: http://dx.10.1111/ejn.16254
• 发表时间: 2024
• 期刊: The European journal of neuroscience
• 作者: Aabdien A

Neuroimmune disorders in COVID-19.

COVID-19 中的神经免疫性疾病。

• DOI: http://dx.10.1007/s00415-022-11050-w
• 发表时间: 2022
• 期刊: Journal of neurology
• 影响因子: 6
• 作者: Ariño H

Neurodevelopmental functions of CHD8: new insights and questions

CHD8 的神经发育功能：新见解和问题

• DOI: 10.1042/bst20220926
• 发表时间: 2024-01-30
• 期刊: Biochemical Society Transactions
• 影响因子: 3.9
• 作者: M. A. Basson

The chromatin remodelling factor Chd7 protects auditory neurons and sensory hair cells from stress-induced degeneration

染色质重塑因子 Chd7 保护听觉神经元和感觉毛细胞免受压力引起的退化

• DOI: http://dx.10.1038/s42003-021-02788-6
• 发表时间: 2021
• 期刊: Communications Biology
• 影响因子: 5.9
• 作者: Ahmed M