MECHANISMS OF HEMATOPOIESIS IN AIDS

艾滋病的造血机制

• 批准号: 6183550
• 负责人: David T Scadden
• 金额: $ 41.27万
• 依托单位: MASSACHUSETTS GENERAL HOSPITAL
• 依托单位国家: 美国
• 财政年份: 1991
• 资助国家: 美国
• 起止时间: 1991-02-01 至 2001-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6183550
• 关键词: AIDS; T lymphocyte; antiAIDS agent; bone marrow; cell differentiation; cellular pathology; drug adverse effect; gene expression; hematopoiesis; hematopoietic stem cells; human immunodeficiency virus 1; human tissue; polymerase chain reaction; tissue /cell culture

DESCRIPTION: This grant application is aimed at improving the understanding of the contribution of impaired T cell production to the effects of HIV. First, the investigator will examineif there is impairment in lymphopoietic capacity of HIV+ bone marrows. Second, the investigator will examine the expression of gene products that regulate hematopoiesis. Third, the investigator will examine the effects of AIDS medications on T cell production.

描述：本拨款申请旨在增进对 T 细胞生成受损对 HIV 影响的贡献。 首先，研究者将检查淋巴细胞生成功能是否受损 HIV+ 骨髓的容量。 其次，调查员将检查 调节造血的基因产物的表达。 第三， 研究人员将检查艾滋病药物对 T 细胞的影响 生产。