INTERACTIONS OF CRF AND NE IN NUCLEUS ACCUMBENS SHELL

伏核壳中 CRF 和 NE 的相互作用

• 批准号: 6185700
• 负责人: VAISHALI P BAKSHI
• 金额: $ 3.47万
• 依托单位: UNIVERSITY OF WISCONSIN-MADISON
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-05-01 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/6185700
• 关键词: Animalia; behavioral /social science research tag; corticotropin releasing factor; drug interactions; ethology; experimental brain lesion; hormone regulation /control mechanism; immunocytochemistry; in situ hybridization; neuroendocrine system; norepinephrine; nucleus accumbens; protein localization

DESCRIPTION (applicant's abstract): Dysregulation of the system has been associated with psychiatric disorders such as depression. CRF is thought to function as a central mediator of integrated autonomic, neuroendocrine, and behavioral responses to stress. The behavioral effects of CRF often resemble conditions of mild stress or arousal; norepinephrine (NE) has been proposed to regulate arousal and vigilance by enhancing the salience of sensory inputs to neurons. Thus, CRF and NE could interact to modulate the fundamental behavioral profile that an organism exhibits in response to its changing environmental conditions. The shell subregion of the nucleus accumbens (AcbSh) contains dense concentrations of CRF and NE, and is thought to integrate information processed in cortical, limbic, autonomic, and motor areas; AcbSh is thereby very well positioned to regulate the basic behavioral profile of an organism in response to its dynamic external milieu. AcbSh could thus be an important site in which CRF and NE systems act and possibly interact in the regulation of an organism's fundamental behavioral repertoire. The present proposal seeks to examine the behavioral roles of CRF and NE in the AcbSh, and the neurochemical and anatomical substrates of possible interactions between these systems within this region. This work may provide an important first step in characterizing the basic mechanisms through which an organism maintains behavioral homeostasis; understanding of these substrates might ultimately shed insight into some of the processes that become dysregulated in illnesses such as depression and anxiety disorders that are characterized by the expression of inappropriate behavioral responses to environmental contingencies.

描述（申请人的摘要）：系统的失调与抑郁症等精神疾病有关。 CRF 被认为是对压力的综合自主神经、神经内分泌和行为反应的中心调节因子。 CRF 的行为影响通常类似于轻度压力或兴奋的情况；去甲肾上腺素（NE）被认为可以通过增强神经元感觉输入的显着性来调节觉醒和警觉性。因此，CRF 和 NE 可以相互作用来调节生物体响应其不断变化的环境条件而表现出的基本行为特征。伏隔核 (AcbSh) 的壳亚区域含有密集的 CRF 和 NE，被认为整合了皮质、边缘、自主神经和运动区域处理的信息；因此，AcbSh 非常适合调节生物体的基本行为特征，以响应其动态的外部环境。因此，AcbSh 可能是 CRF 和 NE 系统在生物体基本行为库的调节中发挥作用并可能相互作用的重要场所。本提案旨在研究 AcbSh 中 CRF 和 NE 的行为作用，以及该区域内这些系统之间可能相互作用的神经化学和解剖学基础。这项工作可能为表征生物体维持行为稳态的基本机制提供了重要的第一步。对这些底物的了解可能最终有助于深入了解抑郁症和焦虑症等疾病中一些失调的过程，这些疾病的特点是对环境突发事件表现出不适当的行为反应。