RENEWAL OF THE NEW JERSEY CFS CRC

更新新泽西州 CFS CRC

• 批准号: 6169694
• 负责人: Benjamin Natelson
• 金额: $ 76.44万
• 依托单位: UNIV OF MED/DENT OF NJ-NJ MEDICAL SCHOOL
• 依托单位国家: 美国
• 财政年份: 1990
• 资助国家: 美国
• 起止时间: 1990-09-30 至 2003-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6169694
• 关键词: chronic fatigue syndrome; cooperative study

We propose to continue the work of our CFS CRC. The central theme and goal of the Center is to stratify CFS patients based on differences in cardiovascular and neuropsychological function. The purpose of our Center will be to continue to use the syndromic approach to identify subgroups of patients with different putative organic causes for their fatiguing illness. In the past grant cycle, we have identified two such -- one implicating the brain and another implicating abnormalities in peripheral cardiovascular function. We plan to bring in CFS patients and categorize them based on the variables that track these putative organic causes -- namely cognitive dysfunction and cardiac stroke volume. By using a median split approach, we will have data from 4 groups of patients and can make a priori hypotheses about which group will show the biggest differences from our sedentary healthy controls during experimental testing. The work we propose begins at the molecular level of serotonin receptor function and spinal fluid constitution, moves on to the physiological level in experiments on brain blood flow, on the structure and function of the heart, and on orthostatic intolerance and continues to the system level in a longitudinal study that follows the illness patterns of different subsets of CFS patients over time. Thanks to prior NIAID support, we have put together a broad team of experts -- all with major interests in understanding CFS. The group is headed by a neurologist-scientist and is comprised of psychologists, physiologists expert in behavioral medicine, exercise and activity assessments, and a superb statistician. New collaborations were initiated - one with a physician in Germany who is expert in autoantibodies and another with an NIMH researcher expert in central factors in fatiguing illness. We propose a three tiered strategy for the next 5 years of our Center's activities. First, we will use ideas synthesized from data generated from our original Center to fuel new studies aimed at understanding the abnormalities and/or causes of CFS. The second tier uses probes known to uncover subtle abnormalities in brain and cardiovascular function. The third tier is a longitudinal study of CFS to determine the pattern of illness over time and how illness and psychosocial factors interact over time.

我们建议继续开展粮安委儿童中心的工作。 该中心的中心主题和目标是根据心血管和神经心理功能的差异对 CFS 患者进行分层。我们中心的目的是继续使用综合征方法来识别具有不同推定器质性原因导致疲劳性疾病的患者亚组。在过去的资助周期中，我们已经确定了两种这样的情况——一种与大脑有关，另一种与周围心血管功能异常有关。 我们计划引入慢性疲劳综合症患者，并根据追踪这些假定的器质性原因的变量（即认知功能障碍和心搏量）对他们进行分类。 通过使用中值分割方法，我们将获得 4 组患者的数据，并可以对实验测试期间哪组患者与久坐的健康对照组表现出最大差异做出先验假设。我们建议的工作从血清素受体功能和脊髓液构成的分子水平开始，在脑血流、心脏结构和功能、直立不耐受实验中进入生理水平，并继续到系统水平在一项追踪慢性疲劳综合症患者不同亚群随时间变化的疾病模式的纵向研究中。 感谢 NIAID 之前的支持，我们组建了一个广泛的专家团队——所有专家都对了解 CFS 感兴趣。 该小组由一位神经学家兼科学家领导，成员包括心理学家、行为医学、运动和活动评估方面的专家生理学家以及一位出色的统计学家。 新的合作开始了——其中一项是与一位德国的自身抗体专家合作，另一项是与一位 NIMH 研究人员在疲劳疾病的核心因素方面的专家合作。我们为中心未来 5 年的活动提出了三层战略。 首先，我们将利用从我们原始中心生成的数据综合得出的想法来推动旨在了解 CFS 异常和/或原因的新研究。 第二层使用已知的探针来发现大脑和心血管功能的细微异常。 第三层是对 CFS 的纵向研究，以确定疾病随时间的变化模式以及疾病和心理社会因素如何随时间相互作用。