RENEWAL OF THE NEW JERSEY CFS CRC

更新新泽西州 CFS CRC

• 批准号: 6169694
• 负责人: Benjamin Natelson
• 金额: $ 76.44万
• 依托单位: UNIV OF MED/DENT OF NJ-NJ MEDICAL SCHOOL
• 依托单位国家: 美国
• 财政年份: 1990
• 资助国家: 美国
• 起止时间: 1990-09-30 至 2003-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6169694
• 关键词: chronic fatigue syndrome; cooperative study

We propose to continue the work of our CFS CRC. The central theme and goal of the Center is to stratify CFS patients based on differences in cardiovascular and neuropsychological function. The purpose of our Center will be to continue to use the syndromic approach to identify subgroups of patients with different putative organic causes for their fatiguing illness. In the past grant cycle, we have identified two such -- one implicating the brain and another implicating abnormalities in peripheral cardiovascular function. We plan to bring in CFS patients and categorize them based on the variables that track these putative organic causes -- namely cognitive dysfunction and cardiac stroke volume. By using a median split approach, we will have data from 4 groups of patients and can make a priori hypotheses about which group will show the biggest differences from our sedentary healthy controls during experimental testing. The work we propose begins at the molecular level of serotonin receptor function and spinal fluid constitution, moves on to the physiological level in experiments on brain blood flow, on the structure and function of the heart, and on orthostatic intolerance and continues to the system level in a longitudinal study that follows the illness patterns of different subsets of CFS patients over time. Thanks to prior NIAID support, we have put together a broad team of experts -- all with major interests in understanding CFS. The group is headed by a neurologist-scientist and is comprised of psychologists, physiologists expert in behavioral medicine, exercise and activity assessments, and a superb statistician. New collaborations were initiated - one with a physician in Germany who is expert in autoantibodies and another with an NIMH researcher expert in central factors in fatiguing illness. We propose a three tiered strategy for the next 5 years of our Center's activities. First, we will use ideas synthesized from data generated from our original Center to fuel new studies aimed at understanding the abnormalities and/or causes of CFS. The second tier uses probes known to uncover subtle abnormalities in brain and cardiovascular function. The third tier is a longitudinal study of CFS to determine the pattern of illness over time and how illness and psychosocial factors interact over time.

我们建议继续CFS CRC的工作。 该中心的中心主题和目标是根据心血管和神经心理学功能的差异对CFS患者进行分层。我们中心的目的是继续使用综合征方法来识别患有不同推定有机病因的患者的亚组，以使其疲劳疾病。在过去的赠款周期中，我们已经确定了两个这样的赠款 - 一个暗示大脑，另一个暗示外周心血管功能异常。 我们计划根据跟踪这些假定的有机原因的变量（即认知功能障碍和心脏中风量）来引入CFS患者并将其分类。 通过使用中位分式方法，我们将获得来自4组患者的数据，并可以先验假设哪个组将在实验测试期间显示与我们久坐的健康对照的最大差异。我们提出的工作始于5-羟色胺受体功能和脊柱液体的分子水平，在脑血流，心脏的结构和功能以及到达稳定的不耐受性方面的实验中，一直延伸到生理水平，并在纵向研究中持续到系统水平，该研究遵循CFS患者超过CFS患者的疾病的纵向研究。 多亏了先前的NIAID支持，我们组成了一个广泛的专家团队 - 所有这些都对了解CFS有重大兴趣。 该小组由神经科医生科学家领导，由心理学家，行为医学，运动和活动评估的生理学家专家以及一位出色的统计学家组成。 开始了新的合作 - 一项与德国的医生一起是自身抗体专家，另一次是NIMH研究者在疲劳疾病方面的中心因素方面的专家。我们在中心活动的接下来的5年中提出了三个分层的策略。 首先，我们将使用从原始中心生成的数据中综合的想法到旨在了解CFS异常和/或原因的新研究。 第二层使用已知的探针来发现大脑和心血管功能的微妙异常。 第三层是对CFS的纵向研究，旨在确定疾病的模式，以及疾病和社会心理因素如何随着时间的推移相互作用。