AUTONOMIC FUNCTION IN EXERCISE TRAINED HYPERTENSIVES

运动训练过的高血压患者的自主功能

基本信息

批准号：
6184206
负责人：
STEPHEN E DICARLO
金额：
$ 19.9万
依托单位：
WAYNE STATE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
1997
资助国家：
美国
起止时间：
1997-08-20 至 2002-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/6184206
关键词：
arginine vasopressin autonomic nervous system baroreceptors baroreflex blood flow measurement catecholamines exercise gender difference heart rate hormone regulation /control mechanism hypertension laboratory rat neuroregulation renin vascular resistance vascular smooth muscle nervous control

项目摘要

DESCRIPTION (Adapted from the applicant's abstract): Hypertension is the single most important contributing factor to both coronary heart disease and stroke, the two leading causes of death in the United States. Nonfatal and fatal cardiovascular diseases including coronary heart disease, ventricular arrhythmias and stroke, as well as renal disease and all-cause mortality increase progressively with higher levels of arterial pressure. In addition, both arterial and cardiopulmonary baroreflexes are less effective in controlling the circulation in hypertensive subjects. Cardiovascular mortality increases progressively with reduced baroreflex sensitivity. A limited number of studies performed with hypertensive subjects reported that endurance exercise training increased the sensitivity of the arterial baroreflex. An increased baroreflex gain may have cardioprotective effects and could be beneficial to patients at high risk for sudden cardiac death. A reduction in the incidence of sudden cardiac death among postinfarction patients participating in a multifactorial intervention program that included exercise has been reported. Therefore, this proposal is designed to determine the effect of endurance exercise training on the arterial and cardiopulmonary baroreflex regulation of the cardiovascular system in hypertensive rats. Specifically, the interaction of the arterial and cardiopulmonary baroreflex on the regulation of sympathetic nerve activity, regional blood flow, arterial pressure, heart rate and hormonal regulation (renin and arginine vasopressin) at rest and during exercise will be studied in sedentary and exercise trained hypertensive rats. The influence of peripheral (afferent activity) and central mechanisms in mediating the autonomic adaptations associated with exercise training will also be examined. These studies will provide a better understanding of the regulation of the neurohumoral drive to the circulation, the effect of exercise training on this regulation and the influence of central and peripheral mechanisms in mediating the autonomic adaptations associated with exercise training in hypertensive rats.

描述（根据申请人的摘要改编）：高血压是冠心病和中风是美国的两个主要死亡原因。非致命和致命的心血管疾病，包括冠心病，心室心律不齐和中风，以及肾脏疾病和全因死亡率随着动脉压的较高水平逐渐增加。在此外，动脉和心肺动反射剂的效果较低在控制高血压受试者的循环中。心血管死亡率随着压力反射灵敏度的降低而逐渐增加。一个高血压受试者进行的研究数量有限。耐力运动训练提高了动脉的敏感性 BaroreFlex。降压体增益增加可能具有心脏保护作用并且可能对患心脏猝死的高风险患者有益。炎后心脏突然死亡的发病率降低参加多因素干预计划的患者据报道包括运动。因此，该提案的设计确定耐力运动训练对动脉的影响心血管系统的心肺动反射调节高血压大鼠。具体而言，动脉和心肺动反射有关交感神经活动的调节，区域血流，动脉压，心率和激素调节（肾素和精氨酸加压素）休息和运动过程中将研究在久坐和运动训练的高血压大鼠中。影响介导的外围（传入活动）和中心机制与运动训练相关的自主改编也将是检查。这些研究将更好地理解对循环的神经瘤驱动器的调节对此法规的锻炼训练以及中央的影响介导与相关的自主神经适应的外围机制高血压大鼠的运动训练。

项目成果

期刊论文数量（13）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Post-exercise elevations in sympathetic nerve activity and baroreflex function in normotensive rabbits.

血压正常的兔子运动后交感神经活动和压力反射功能升高。

DOI：
10.1081/ceh-100100082
发表时间：
2000
期刊：
Clinical and experimental hypertension (New York, N.Y. : 1993)
影响因子：
0
作者：
Howard,MG;Collins,HL;Dicarlo,SE
通讯作者：
Dicarlo,SE

Postexercise alpha-adrenergic receptor hyporesponsiveness in hypertensive rats is due to nitric oxide.

高血压大鼠运动后α-肾上腺素能受体反应低下是由于一氧化氮所致。

DOI：
10.1152/ajpregu.00490.2001
发表时间：
2002
期刊：
American journal of physiology. Regulatory, integrative and comparative physiology
影响因子：
0
作者：
Rao,SumangalaP;Collins,HeidiL;DiCarlo,StephenE
通讯作者：
DiCarlo,StephenE

Phenotypic differences in cardiovascular regulation in inbred rat models of aerobic capacity.

有氧能力近交大鼠模型心血管调节的表型差异。