SUBCORTICAL MICROVASCULAR DISEASE IN DEPRESSION

抑郁症中的皮层下微血管疾病

• 批准号: 6139335
• 负责人: STEPHEN P SALLOWAY
• 金额: $ 15.39万
• 依托单位: RHODE ISLAND HOSPITAL
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-01-01 至 2003-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6139335
• 关键词: aging; apolipoproteins; brain circulation; cerebrovascular disorders; clinical research; cognition disorders; comorbidity; depression; disease /disorder etiology; disease /disorder onset; functional ability; geriatrics; human middle age (35-64); human old age (65+); human subject; hypertension; memory disorders; microcirculation; psychomotor disorders

The objective of this five year Mentored Clinical Scientist Development Award is to become an independent investigator in the pathogenesis, prevention, and treatment of subcortical microvascular disease in geriatric depression. The award will help the nominee develop skills in the following areas: clinical research methodology and statistics, quantitative magnetic resonance imaging (MRI) analysis, pathogenesis of cerebral small artery disease, and assessment of cognitive function and clinical manifestations of geriatric depression. These skills will be utilized to conduct a pilot study of the role of subcortical microvascular disease in geriatric depression. The study will use a case control design to compare two groups of geriatric depressed inpatients with and without high levels of subcortical microvascular disease. The specific aim is to look for differences in hypertensive burden, cognitive function, phenomenology of depression, and rate of decline in cognition and activities of daily living (ADLs). Subsidiary analyses will correlate the regional distribution of MRI hyperintensities with the pattern of cognitive dysfunction, and will evaluate the presence of apolipoprotein E4 alleles as a marker for the development of microvascular disease. The findings from this study should have important implications for prevention, prognosis, and treatment of geriatric depression associated with microvascular disease. The nominee plans to submit an RO1 level grant on subcortical microvascular disease in geriatric depression based on results obtained in the pilot study prior to the completion of the award. The nominee plans to develop a high quality morphometric imaging laboratory which will be used as a resource for a number of clinical studies in the departments of psychiatry and clinical neurosciences at Brown. The nominee further plans on assuming a leadership role in developing a post-doctoral clinical research training program in geriatric neuropsychiatry at Brown University.

本五年指导临床科学家发展的目标 奖项是成为发病机制的独立研究者， 皮层下微血管疾病的预防和治疗 老年抑郁症。 该奖项将帮助被提名者发展技能 在以下领域：临床研究方法和统计， 定量磁共振成像 (MRI) 分析、发病机制 脑小动脉疾病以及认知功能和认知功能的评估 老年抑郁症的临床表现。 这些技能将用于对以下方面的作用进行试点研究： 老年抑郁症的皮层下微血管疾病。 研究 将使用病例对照设计来比较两组老年人 患有或不患有高皮质下水平的抑郁症住院患者 微血管疾病。 具体目标是寻找差异 高血压负担、认知功能、抑郁现象学、 以及认知和日常生活活动 (ADL) 下降的速度。 辅助分析将关联 MRI 的区域分布 具有认知功能障碍模式的高信号，并且会 评估载脂蛋白 E4 等位基因的存在作为 微血管疾病的发展。 这项研究的结果 对预防、预后和治疗应该具有重要意义 治疗与微血管疾病相关的老年抑郁症。 被提名者计划提交皮层下的 RO1 级资助 基于所获得的结果的老年抑郁症的微血管疾病 在获奖完成之前的试点研究中。被提名者 计划开发一个高质量的形态测量成像实验室 将被用作许多临床研究的资源 布朗大学精神病学和临床神经科学系。 这 被提名人进一步计划在制定 老年医学博士后临床研究培训项目 布朗大学神经精神病学。