STRUCTURE & FUNCTION OF BACTERIAL VIRUSES

结构

• 批准号: 6282458
• 负责人: ROGER W HENDRIX
• 金额: $ 1.17万
• 依托单位: MELLON PITTS CORPORATION (MPC CORP)
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-08-01 至 1999-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6282458
• 关键词: bacteria; biomedical resource; genetics; genome; virus; bacteria; biomedical resource; genetics; genome; virus

We have determined the DNA sequence of one bacteriophage genome and will determine about ten more, and roughly 15 more are available in public databases. We will use PSC facilities to assemble our DNA sequence data to produce finished sequences and then to analyze those sequences. Analysis will include, first, analysis of individual genome sequences to determine the genetic structure of the individual viruses and , second, comparisions among the newly determined sequences and other DNA sequences in the GenBank database In particular, we will focus on comparisons between related bacteriophage sequences, at the level of individual genes and proteins and at the level of the entire genomes. Information from these comparisons will address issues of structure/function relationships in the viral proteins and of genetic mechanisms operating in the evolution of viral genomes.

我们已经确定了一个噬菌体基因组的DNA序列 并将确定大约十个，大约有15个可用 在公共数据库中。 我们将使用PSC设施组装DNA 序列数据以产生完成序列，然后分析这些序列 序列。 分析将首先包括对个人的分析 基因组序列确定个体的遗传结构 病毒，其次是新确定的比较 GenBank数据库中的序列和其他DNA序列 特别是，我们将重点介绍相关噬菌体之间的比较 序列，在单个基因和蛋白质的水平上以及在 整个基因组水平。 这些比较中的信息将 解决病毒中结构/功能关系的问题 蛋白质和在病毒进化中运行的遗传机制 基因组。