DNA & PROTEIN SEQUENCE ANALYSIS CONSULTING & SOFTWARE DVMT: BIOINFORMATICS, WWW

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• 批准号: 6220210
• 负责人: CHRISTOPHER W BOTKA
• 金额: $ 0.31万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-07-01 至 2000-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6220210
• 关键词: bioengineering /biomedical engineering; biological products; biomedical resource; biotechnology; communication behavior; computers; education; genome; informatics; statistics /biometry; technology /technique

At the Sequence Analysis Consulting Services of UCSF, serving sequence databases and software to over 100 labs including over 1200 people at UCSF, we have the unique advantage of hearing software development priorities directly from the researchers. Areas many scientists feel requires much improvement is user interface and automation. Many bioinformatics programs have yet to take advantage of advances made in areas such as the WWW, Python, Java and the CGI to help improve and simplify the user interface. With the rapid increase in data production through advances in DNA sequencing and DNA micro array technology, there is great interest in developing automated analysis of primary data. Software tools for sequence alignments and structure homology modeling must evolve with the new data produced by efforts such as Genome projects and technologies like DNA arrays. We have designed programs that take advantage of these new technologies to enable the informaticist/scientist to have a more user-friendly and efficient working environment. We have tools in production to help automate the data processing pipeline for primary sequence data and management of these results. We are designing a Perl and Python application for molecular biologists interested in structure to make UNIX sequence analysis and homology modeling tools as easy as browsing the Web. The Computer Graphics Laboratory and its resources offer a unique context for this interdisciplinary work.

在 UCSF 序列分析咨询服务部，服务 为 100 多个实验室（其中包括 1200 多个实验室）提供测序数据库和软件 UCSF 的人们，我们拥有听力软件的独特优势 直接来自研究人员的发展优先事项。 地区很多 科学家认为用户界面需要很大改进 自动化。 许多生物信息学项目尚未利用 WWW、Python、Java 和 CGI​​ 等领域取得的进步 帮助改进和简化用户界面。 随着快速增加 通过 DNA 测序和 DNA 显微技术的进步，在数据生产中 阵列技术，人们对开发自动化有很大兴趣 原始数据分析。 用于序列比对的软件工具 结构同源建模必须随着产生的新数据而发展 基因组项目等努力和 DNA 阵列等技术。 我们 设计了利用这些新技术的程序 使信息学家/科学家能够获得更加用户友好和 高效的工作环境。 我们有生产工具可以提供帮助 自动化主序列数据的数据处理流程和 对这些结果的管理。 我们正在设计一个 Perl 和 Python 对结构感兴趣的分子生物学家的应用程序 UNIX 序列分析和同源建模工具就像浏览一样简单 网络。计算机图形实验室及其资源提供了 这项跨学科工作的独特背景。