Investigating the Effect of the Menstrual Cycle on Social Stress in Early Psychosis Through Ecological Momentary Assessment

通过生态瞬时评估研究月经周期对早期精神病社会压力的影响

• 批准号: MR/W015943/1
• 负责人: Thomas Reilly
• 金额: $ 34.97万
• 依托单位: King's College London
• 依托单位国家: 英国
• 项目类别: Fellowship
• 财政年份: 2022
• 资助国家: 英国
• 起止时间: 2022 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=MR%2FW015943%2F1
• 关键词: Investigating; Effect; Menstrual; Cycle; Social

Psychosis is a severe mental illness which has major costs both to society and to individuals affected. Relapses of psychosis are incredibly disruptive for patients' lives. For women who have psychosis, the time around their menstrual period carries a particularly high risk for relapse. Patient groups report that the menstrual cycle is an important topic for consideration but it has been relatively overlooked in research to date. The reasons why the menstrual cycle should affect women with psychosis are not clear but may relate to social stress. Response to stress, particularly in social situations, seems to be important in the development of psychosis. This is the case for people who have recently developed a psychotic illness as well as those who are at higher risk of psychosis. Response to stress also varies across the menstrual cycle, which could explain why psychosis seems to worsen around the time of menstruation. We will use a newly developed smartphone app, Social Mind to measure daily responses to stress. Smartphone apps offer a convenient way for participants to measure both the menstrual cycle and response to stress. They can also be used to monitor social withdrawal, measured through reduced movement. The app will use phone movement data to passively measure social withdrawal. The app will be used by participants to record their menstrual periods. Women who are either at risk of psychosis or who are experiencing their first episode of psychosis will be asked to complete these measures. For comparison, healthy women will complete the measures as well.We will analyse whether social stress and withdrawal are affected by the menstrual cycle. We will examine whether relapse of psychosis is more likely at certain times of the cycle and if stress influences it. We will compare differences between women who are experiencing psychosis, those at risk of psychosis and those not affected by mental health problems.It is hoped by understanding how the menstrual affects response to stress in psychosis, new targets for treatment will be identified. At present, all antipsychotic medications work in a similar way and have troublesome side-effects. Medications that stabilise hormonal fluctuations represent a completely different approach that could work for some women.

精神病是一种严重的精神疾病，对社会和受影响的个人都有重大成本。精神病的复发对患者的生活产生了令人难以置信的破坏性。对于患有精神病的女性，月经周期周围的时间具有复发的风险特别高。患者群体报告说，月经周期是要考虑的重要主题，但迄今为止的研究相对忽略了。月经周期应影响精神病女性的原因尚不清楚，但可能与社会压力有关。对压力的反应，尤其是在社会情况下，似乎在精神病的发展中很重要。对于最近患有精神病疾病以及患有精神病风险较高的人来说，情况就是这种情况。对压力的反应在整个月经周期也有所不同，这可以解释为什么精神病在月经期间似乎会恶化。我们将使用新开发的智能手机应用程序，社交头脑来衡量日常对压力的反应。智能手机应用程序为参与者提供了一种衡量月经周期和对压力反应的方便方式。它们还可以用来监测通过减少运动来衡量的社交退出。该应用将使用电话移动数据被动地衡量社交退出。参与者将使用该应用程序记录其月经期。将要求有精神病风险或正在经历精神病第一集的妇女完成这些措施。为了进行比较，健康女性也将完成这些措施。我们将分析社会压力和戒断是否受月经周期的影响。我们将检查精神病复发是否在周期的某些时候更有可能影响。我们将比较患有精神病，患有精神病风险的女性与不受心理健康问题影响的女性之间的差异。希望通过了解月经对精神病压力的反应如何确定新的治疗目标，从而确定了新的治疗目标。目前，所有抗精神病药都以类似的方式起作用，并且具有麻烦的副作用。稳定激素波动的药物代表了一种完全不同的方法，可以对某些女性有用。

项目成果

Systematic review of the association between adverse life events and the onset and relapse of postpartum psychosis.

• DOI: 10.3389/fpsyt.2023.1154557
• 发表时间: 2023
• 期刊: FRONTIERS IN PSYCHIATRY
• 影响因子: 4.7
• 作者: Reilly, Thomas J.;Roberts, Emma;De La Bastida, Vanessa Charlotte Sagnay;McGuire, Philip;Dazzan, Paola;Cullen, Alexis E.
• 通讯作者: Cullen, Alexis E.

Intermittent selective serotonin reuptake inhibitors for premenstrual syndromes: A systematic review and meta-analysis of randomised trials.

• DOI: 10.1177/02698811221099645
• 发表时间: 2023-03
• 期刊: JOURNAL OF PSYCHOPHARMACOLOGY
• 影响因子: 4.1
• 作者: Reilly, Thomas J.;Wallman, Phoebe;Clark, Ivana;Knox, Clare-Louise;Craig, Michael C.;Taylor, David
• 通讯作者: Taylor, David

The prevalence of premenstrual dysphoric disorder: Systematic review and meta-analysis

经前焦虑障碍的患病率：系统回顾和荟萃分析

• DOI: 10.1016/j.jad.2024.01.066
• 发表时间: 2024
• 期刊: Journal of Affective Disorders
• 影响因子: 6.6
• 作者: Reilly T

A case series of premenstrual disorders presenting to the UK's National Female Hormone Clinic.

• DOI: 10.1192/bjb.2022.63
• 发表时间: 2023-10
• 期刊: BJPSYCH BULLETIN
• 影响因子: 2.6
• 作者: Reilly, Thomas J.;Knox, Clare-Louise;Marsh, Michael S.;Craig, Michael C.
• 通讯作者: Craig, Michael C.

Point of care assay for blood aripiprazole concentrations: development, validation and utility.

血液阿立哌唑浓度的护理点测定：开发、验证和实用性。

• DOI: 10.1192/bjp.2023.58
• 发表时间: 2023
• 期刊: the journal of mental science
• 作者: Atkins M