MRC Centre for Neurodevelopmental Disorders

MRC 神经发育障碍中心

• 批准号: MR/W006251/1
• 负责人: Oscar Marin
• 金额: $ 243.5万
• 依托单位: King's College London
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2021
• 资助国家: 英国
• 起止时间: 2021 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=MR%2FW006251%2F1
• 关键词: MRC; Centre; Neurodevelopmental; Disorders

Neurodevelopmental disorders are a group of conditions which are caused by an alteration in the development of the nervous system. Intellectual disabilities, autism spectrum disorder and many forms of epilepsy are caused by disturbances in the typical programme of brain development. Even psychosis and related disorders, which typically emerge later in life, are thought to have a developmental origin. Developmental brain disorders often cause life-long disability and current treatments, at best, are merely palliative.Brain development is a highly orchestrated process directed by genetic information and influenced by many environmental factors. The human brain develops over two decades, a very substantial part of our life. During that time, the brain grows from a microscopic structure to a remarkable organ that enables us to interact with the physical world, communicate, learn and imagine the unknown. Alterations in this very protracted program result in neurodevelopmental disorders. Developmental brain disorders arise through a combination of genetic and environmental (non-genetic) influences. Research over the past decade has shown that genetic changes are the most important risk factor for developmental brain disorders, independently of whether they manifest early in life, such as autism spectrum disorder or only become clinically detectable in young adults, such as psychosis. Recent advances in human genetics have identified specific mutations with these disorders. Unfortunately, we still do not understand how these mutations and concomitant environmental insults cause neurodevelopmental disorders. When the Centre was established five years ago, our vision was to build a world-class Centre at King's College London with research programmes that will transform our understanding of the origin of neurodevelopmental disorders. We have created a research environment in which we are effectively dissolving some of the boundaries preventing our progress, such as the lack of interaction between basic and clinical scientists and between clinical specialists working on different but related disorders. At the core of our strategy is an innovative PhD Programme that is training a new generation of scientists with the skills to comfortably work across basic and clinical research settings and sustain collaborations across groups.The crucial limitation for the design of new medicines for neurodevelopmental disorders continues to be our insufficient understanding of the changes that occur in the brain of affected individuals. In the next five years, the main focus of our efforts will remain the exploration of the biological mechanisms underlying neurodevelopmental disorders. In the long term, we aim to translate the new knowledge into clinical advances that change the lives of affected individuals and their families, in collaboration with industrial partners, other research centres and patient associations.

神经发育障碍是由神经系统发展改变引起的一组疾病。智力障碍，自闭症谱系障碍和多种形式的癫痫病是由典型的大脑发育计划中的干扰引起的。即使是精神病和相关疾病，通常在生活中通常会出现，也被认为具有发育起源。发育性脑部疾病通常会导致终身残疾，充其量只是姑息治疗。脑发育是一个由遗传信息引导的高度精心策划的过程，受许多环境因素的影响。人类大脑发展了二十年，这是我们生活中非常重要的一部分。在此期间，大脑从显微镜结构变成了一个显着的器官，使我们能够与物理世界互动，进行交流，学习和想象未知。这个非常旷日持久的程序的改变导致神经发育障碍。发育性脑部疾病是通过遗传和环境（非遗传）影响的结合而产生的。在过去的十年中，研究表明，遗传变化是发育性脑部疾病的最重要危险因素，独立于生命早期表现出来，例如自闭症谱系障碍或仅在年轻人（例如精神病）中被临床检测到。人类遗传学的最新进展已经确定了这些疾病的特定突变。不幸的是，我们仍然不了解这些突变和随之而来的环境侮辱如何引起神经发育障碍。该中心成立于五年前，我们的愿景是在伦敦国王学院建立一个世界一流的中心，其研究计划将改变我们对神经发育障碍起源的理解。我们创造了一个研究环境，在该环境中，我们正在有效地消除一些阻止我们进步的边界，例如基本科学家和临床科学家之间以及研究不同但相关疾病的临床专家之间的相互作用。我们战略的核心是一个创新的博士计划，该计划正在培训新一代的科学家，具有在基本和临床研究环境中舒适地工作并维持跨小组的合作的技能。设计新药物的神经发育障碍的关键限制仍然是我们对受影响个人大脑中发生的变化的充分理解。在接下来的五年中，我们努力的主要重点将继续探索神经发育障碍潜在的生物学机制。从长远来看，我们旨在将新知识转化为与工业伙伴，其他研究中心和患者协会合作改变受影响个人及其家人生活的临床进步。

项目成果

Atypical Neurogenesis in Induced Pluripotent Stem Cells From Autistic Individuals.

• DOI: 10.1016/j.biopsych.2020.06.014
• 发表时间: 2021-03-01
• 期刊: Biological psychiatry
• 影响因子: 10.6
• 作者: Adhya D;Swarup V;Nagy R;Dutan L;Shum C;Valencia-Alarcón EP;Jozwik KM;Mendez MA;Horder J;Loth E;Nowosiad P;Lee I;Skuse D;Flinter FA;Murphy D;McAlonan G;Geschwind DH;Price J;Carroll J;Srivastava DP;Baron-Cohen S
• 通讯作者: Baron-Cohen S

Refinements to rodent head fixation and fluid/food control for neuroscience

• DOI: 10.1016/j.jneumeth.2022.109705
• 发表时间: 2022-09-15
• 期刊: JOURNAL OF NEUROSCIENCE METHODS
• 影响因子: 3
• 作者: Barkus, Chris;Bergmann, Caroline;Prescott, Mark J.
• 通讯作者: Prescott, Mark J.

Tissue optimization strategies for high-quality ex vivo diffusion imaging.

• DOI: 10.1002/nbm.4866
• 发表时间: 2023-03
• 期刊: NMR in biomedicine
• 影响因子: 2.9

Neuroimmune disorders in COVID-19.

• DOI: 10.1007/s00415-022-11050-w
• 发表时间: 2022-06
• 期刊: Journal of neurology
• 影响因子: 6
• 作者: Ariño H;Heartshorne R;Michael BD;Nicholson TR;Vincent A;Pollak TA;Vogrig A
• 通讯作者: Vogrig A

Inositol treatment inhibits medulloblastoma through suppression of epigenetic-driven metabolic adaptation.

• DOI: 10.1038/s41467-021-22379-7
• 发表时间: 2021-04-12
• 期刊: Nature communications
• 影响因子: 16.6
• 作者: Badodi S;Pomella N;Zhang X;Rosser G;Whittingham J;Niklison-Chirou MV;Lim YM;Brandner S;Morrison G;Pollard SM;Bennett CD;Clifford SC;Peet A;Basson MA;Marino S
• 通讯作者: Marino S