AFRICAN AMERICAN STUDY OF KIDNEY DISEASE (AASK)

非裔美国人肾脏疾病研究 (AASK)

• 批准号: 6218198
• 负责人: LAWRENCE JOHN APPEL
• 金额: $ 0.23万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-12-01 至 1999-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6218198
• 关键词: ACE inhibitors; African American; antihypertensive agents; beta antiadrenergic agent; calcium channel blockers; cardiovascular disorder chemotherapy; clinical research; clinical trials; drug screening /evaluation; human subject; human therapy evaluation; kidney disorder chemotherapy; kidney function; longitudinal human study; renal hypertension

This study is a randomized clinical trial that tests the impact of 2 different levels of blood pressure control (usual level versus lower level) and 3 different types of antihypertensive drug regimens (beta-blocker, calcium channel blocker, and angiotensinconverting enzyme inhibitor) on renal function over 5 years of follow-up. The study population consists of African-American men and women with early evidence of hypertension-related kidney disease (GFR of 26-65 ml/min/m2). The trial completed recruitment. Follow-up will continue for 2 more years.

本研究是一项随机临床试验，测试 2 种不同水平的血压控制（正常水平与较低水平）和 3 种不同类型的抗高血压药物治疗方案（β 受体阻滞剂、钙通道阻滞剂和血管紧张素转换酶抑制剂）对肾功能的影响。随访5年以上。 研究人群由具有高血压相关肾脏疾病早期证据（GFR 为 26-65 ml/min/m2）的非洲裔美国男性和女性组成。 试验已完成招募。后续还将持续2年。