Limited Competition: Continuation of Chronic Renal Insufficiency Cohort (CRC)

有限竞争：慢性肾功能不全队列 (CRC) 的延续

• 批准号: 7901937
• 负责人: LAWRENCE JOHN APPEL
• 金额: $ 11.47万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-09-04 至 2011-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7901937
• 关键词: African American; Age; Area; Atherosclerosis; Baltimore; Biological; Cardiovascular Diseases; Chronic; Chronic Kidney Insufficiency; Clinical; Cohort Analysis; Cohort Studies; Creatinine; Data; Data Analyses; Data Collection; Databases; Disease; Disease Progression; Economic Factors; Eligibility Determination; Enrollment; Ethnic Origin; Evaluation; Event; Gender; Genetic; Glomerular Filtration Rate; Homocysteine; Homocystine; Hypertension; Incidence; Indigent; Individual; Institution; Intervention Trial; Kidney; Kidney Diseases; Laboratory Study; Lead; Location; Maryland; Measurement; Medical center; Modification; Morbidity - disease rate; Nested Case-Control Study; Observational Study; Outcome; Output; Participant; Persons; Physiological; Population; Positioning Attribute; Predictive Value; Prevalence; Protocols documentation; Publications; Questionnaires; Race; Recruitment Activity; Renal function; Reporting; Research; Research Infrastructure; Research Personnel; Risk Factors; Sex Characteristics; Specific qualifier value; Specimen; System; Telephone; Testing; Training; Universities; Visit; Work; cardiovascular disorder risk; cohort; design; diabetic; disorder risk; follow-up; health care delivery; inflammatory marker; instrument; interest; metropolitan; non-diabetic; oxidative damage; prevent; primary outcome; programs; prospective; research study; salt intake; success

This proposaldescribes the Johns Hopkins-University ofMaryland field centerforthe Prospective Cohort Study of Chronic Renal Insufficiency, also termed CRIC. The incidence and prevalence of endstage kidney disease are relentlessly increasing, along with attendant co-morbidities, particularly cardiovascular disease. CRIC is a longitudinal, observational study that will determine the risk factors for progressionof chronic renal insufficiency and the risk factors for cardiovascular disease in a cohort of individuals with impaired kidney function. Participants will be 3,000 individuals (250 at Hopkins, 250 at Maryland),50% diabetic and 50% non-diabetic, with an estimated glomerular filtration rate (GFR) of 30-70 ml/min/1.73 m2. The primary recruitment strategy will be to identify individuals with an elevated creatinine thatcorresponds to this GFR range. Both Hopkins and U.Maryland have the proven capacity to generate lists of such individuals. These 2 medical centers are the largest health care delivery systems in the Baltimore metropolitan area, which is populated by 1.6 million persons. The locations of the two institutions should acilitate enrollment of a diverse cohort, many of whom will be indigent. Baseline data will be collectedover 3 visits (a brief eligibility visit and 2 subsequent visits). Outcomeswill be ascertained at an annual in-person Follow-up visit and by telephone surveillance. Core measurements will include questionnaires, GFRs chocardiograms, and biological specimens. Study investigators have a proven track record of successfully designing and conducting large-scale, collaborative research studies. Specifically, they havesuccessfully ¿ecruited large cohorts of participants, have achieved high follow-up rates, have collected virtually all of the Imajor measurements proposed in this study, and have made substantive scientific contributions through publication and presentation of their findings. The impressive infrastructure of the two institutions and the (large population of the Baltimore metropolitan area will further enhance the potential for success. Inshort, he Hopkins-U.Maryland field center is extremely well-positioned to accomplish each of the major task: equired of the CRIC field centers and to contribute to the overall success of this vitally important study.

该提议描述了马里兰州现场中心的约翰·霍普金斯大学， 慢性肾功能不全的研究，也称为CRIC。终点的事件和患病率 肾脏疾病不断增加，随之而来的合并症，尤其是心血管 疾病。 CRIC是一项纵向，观察性研究，将确定进展的风险因素 慢性肾功能不全和患有患有的人群的心血管疾病的危险因素 肾功能受损。参与者将是3,000个人（霍普金斯250人，250个在马里兰州），50％ 糖尿病和50％的非糖尿病患者，估计的肾小球过滤率（GFR）为30-70 mL/min/1.73 m2。 主要的招聘策略将是确定具有升高肌酐的人 到这个GFR范围。霍普金斯和U.Maryland都具有生成此类清单的可靠能力 个人。这两个医疗中心是巴尔的摩最大的医疗保健提供系统 大都市地区，有160万人。这两个机构的位置应该 Aclate招收潜水员队列，其中许多人将是贫穷的。将收集基线数据 3次访问（简短的资格访问和随后的2次访问）。将在年度面对面确定的成果 后续访问和电话监视。核心测量将包括问卷，GFRS 巧克力图和生物标本。研究调查人员有成功的记录 设计和进行大规模的协作研究。具体来说，它们是有用的 `大量参与者都达到了较高的随访率，几乎收集了所有的参与者 本研究提出的iMajor测量结果，并通过 他们的发现的出版和呈现。这两个机构的令人印象深刻的基础设施和 （巴尔的摩大都市地区的大量人口将进一步增强成功的潜力。 他霍普金斯 - U.Maryland野战中心非常适合完成每项主要任务： CRIC场中心的必不可少的，并为这项至关重要的研究的整体成功做出贡献。