UMBILICAL VENOUS BLOOD FLOW & AMINOACID TRANSPORT & METABOLISM

脐静脉血流量

• 批准号: 6108429
• 负责人: F BATTAGLIA
• 金额: $ 14.35万
• 依托单位: UNIVERSITY OF COLORADO DENVER
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-07-01 至 2000-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6108429
• 关键词: acid base balance; aminoacid metabolism; aminoacid transport; amniocentesis; blood chemistry; blood flow measurement; cesarean section; clinical research; embryo /fetus monitoring; gestational age; glucose transport; human birth weight; human subject; mother /embryo /fetus nutrition; nutrition related tag; placental transfer; pregnancy; pregnancy circulation disorder; prenatal growth disorder; protein metabolism; respiratory oxygenation; umbilical cord

The specific aims of this project involve clinical studies in normal pregnancies and pregnancies complicated by fetal growth restriction. The study of in vivo amino acid placental transport and metabolism follow-up observations that fetal amino acid concentrations are significantly reduced in fetal growth restricted pregnancies. A non steady state study utilizing stable isoptomers of essential and nonessential amino acids in pregnant women scheduled for cordocentesis examines in vivo transport rates for different groups of amino acids; a.) to define differences in their relative rates of in vivo transport and b.) to test whether amino acid transport is reduced in FGR pregnancies compared to normal pregnancies for all amino acids or a specific subset. Steady state stable isotope methodology is also used to test whether the fetal maternal enrichment ratios for stable isoptomers of amino acids infused into the maternal circulation is lower in FGR pregnancies reflecting decreased transport and increased protein turnover. The relationship of maternal concentration to umbilical uptake for normal and FGR pregnancies is also investigated utilizing data on umbilical arterial venous differences determined at the time of cesarean section. Finally the role of direct measurements of umbilical venous blood flow compared to arterial velocemetry measurements and fetal blood chemistry is examined around the framework of the classification of clinical severity in FGR pregnancies.

该项目的具体目的涉及正常的临床研究 怀孕和怀孕因胎儿生长限制而复杂。 这 研究体内氨基酸胎盘运输和代谢随访 观察到胎儿氨基酸浓度显着 减少胎儿生长受限怀孕。 非稳态研究 利用必需氨基酸和非必要氨基酸的稳定等异构体 安排山宿工的孕妇检查体内运输 不同氨基酸组的速率； a。）定义差异 它们的体内运输和b。）测试是否氨基 与正常相比，FGR妊娠的酸转运减少 所有氨基酸或特定子集的怀孕。 稳定稳定 同位素方法还用于测试胎儿母体是否 注入到该氨基酸的稳定等异位体的富集比 FGR怀孕的孕产妇循环较低，反映出降低 运输并增加蛋白质更新。 孕产妇的关系 正常和FGR怀孕的脐带摄取也集中在 利用脐动脉静脉差异的数据进行了研究 在剖宫产时确定。 最后，直接的作用 与动脉相比，脐带血流量的测量 围绕 FGR妊娠中临床严重程度分类的框架。