SLEEP, DEPRESSION, AND HEALTH RELATED BEHAVIORS

睡眠、抑郁和健康相关行为

• 批准号: 6271645
• 负责人: ROBERT A HICKS
• 金额: $ 11.75万
• 依托单位: SAN JOSE STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-09-01 至 1999-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6271645
• 关键词: REM sleep; behavioral /social science research tag; clinical research; depression; electroencephalography; electromyography; electrophysiology; health behavior; human subject; laboratory rat; learned helplessness; passive smoking; questionnaires; sleep; sleep deprivation; stress; tobacco abuse

The research planned for this grant period includes eight separate studies. All of these studies are designed to measure relationships between aspects of sleep and health-related behaviors. For the most part, each of these studies will generate new, and perhaps important, data that should provide useful insights into the health problems that will be considered. Four of these studies focus on using the demonstrated links between sleep and endogenous depression to provide further and needed validation of two major animal models of human depression (i.e., the behavioral despair and learned helplessness models). Specifically, two of these studies are designed to determine whether the induction of either behavioral despair or learned helplessness alters the architecture of sleep in a manner that is consistent with the deviations from normal electrophysiological patterns that characterize the sleep of patients with endogenous depression. The other two studies in this set are designed to measure the effects of REM sleep depression (i.e., a manipulation that has antidepressant effects) on the depressive-like behaviors that rats exhibit subsequent to the induction of either behavioral despair or learned helplessness. The need for valid animal models of human depression is important and obvious. The significance of this set of studies is that their results may provide less ambiguous support for the validity of one or both of these procedures and in so doing, increase confidence in their usefulness in the study of antidepressant treatments. In addition to this set of four studies, two studies using laboratory animals, are proposed to clarify issues that arise from the application of the procedures for one or both of these models, that is, the sensitivity to pain and fearfulness. The results of these studies should enhance the ability to interpret data derived using either of these animal models of human depression. Finally, two large scale questionnaire studies have been proposed. One of these seeks to gain information that is relevant to the understanding and the remediation of the alarming reductions in both the sleep quantity and quality of college students that we have documented over the past two decades, using, for the first time, a design that considers both gender and ethnic identity as variables. The other questionnaire is an amplification of our recently published research that is designed to comprehensively measure the relationships between cigarette smoking and the quantity and the quality of sleep in a manner that permits the covariation of certain factors that have confounded the interpretation of the relationships between cigarette smoking and sleep in previously published studies. Thus the knowledge generated by both of these questionnaire studies should prove to be useful in altering behaviors that may lead to sleep problems.

计划期间计划的研究包括八个单独的 研究。 所有这些研究旨在衡量关系 在睡眠方面和与健康相关的行为之间。 在大多数情况下， 这些研究中的每一个都将产生新的，也许很重要的数据 应该为健康问题提供有用的见解 经过考虑的。 这些研究中的四项重点是使用所证明的链接 在睡眠和内源性抑郁症之间提供进一步和需要的 验证人类抑郁症的两个主要动物模型（即 行为绝望和学习的无助模型）。 具体来说，两个 这些研究旨在确定诱导是否 行为绝望或学习的无助改变了体系结构 以与正常偏差一致的方式睡眠 电生理模式，表征患者的睡眠 内源性抑郁症。 该集合中的其他两项研究旨在 测量REM睡眠抑郁症的影响（即 对大鼠表现出的抑郁样行为的抗抑郁作用） 在引起任何行为绝望或学到的诱因之后 无助。 需要有效的人类抑郁动物模型的需求是 重要而明显。 这组研究的意义是 他们的结果可能为一个人的有效性提供含糊不清的支持 或这两个程序都这样做，请增加对他们的信心 在研究抗抑郁治疗方面的有用性。 除此之外 提出了四项研究，两项使用实验动物的研究 澄清程序的应用程序引起的问题 或这两种模型，即对痛苦和恐惧的敏感性。 这些研究的结果应增强解释数据的能力 使用这两种动物抑郁症模型得出。 最后， 已经提出了两项​​大规模的问卷研究。 其中之一 试图获得与理解和相关的信息 修复睡眠数量和 我们过去两个的大学生质量 几十年来，首次使用一种考虑性别的设计 和种族身份作为变量。 另一个问卷是 扩增我们最近发表的研究，该研究旨在 全面衡量吸烟和 睡眠的数量和质量以允许的方式 某些因素的协变，这些因素困扰了解释 吸烟和睡觉之间的关系以前 已发表的研究。 因此，这两种知识 问卷研究应证明对改变行为有用 可能导致睡眠问题。