STUDIES ON MODELS OF THE AUDITORY PERIPHERY

听觉外围模型的研究

• 批准号: 6270084
• 负责人: C DANIEL GEISLER
• 金额: $ 21.35万
• 依托单位: UNIVERSITY OF WISCONSIN-MADISON
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-03-01 至 1999-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6270084
• 关键词: acoustic nerve; auditory stimulus; behavioral /social science research tag; biological models; cats; cochlea; ear hair cell; hearing tests; histology; human subject; laboratory rat; microelectrodes; neural information processing; noise; organ of Corti; psychoacoustics; speech; stimulus /response

The overall goal of the project is to provide an accurate and comprehensive computer model of the entire auditory periphery that will simulate the cochlear-partition macromechanical and micromechanical vibrations, the hair-cell voltages, and the auditory-nerve-fiber discharge patterns produced by any acoustic signal presented anywhere in space. This model will be built around a currently working model of cochlear- partition vibrations (hydrodynamics) that was developed during the last grant period. The project has 3 specific aims. The first aim is to improve the accuracy of the current hydrodynamic model. Of particular importance is the low-frequency section of the model, which appears to require fundamentally different simulation than does the high-frequency section. The second aim is to expand the model by including representations of other parts in the peripheral transduction process: the middle and external ears, the hair-cell transduction processes, the hair- cell/afferent-nerve-fiber synapses, and the efferent systems. The third aim is to adapt the model, now representing the cat's periphery, to represent that of the human and the mustached bat.

该项目的总体目标是提供准确且 整个听觉外围的综合计算机模型 模拟耳蜗分区的宏观力学和微观力学 振动、毛细胞电压和听觉神经纤维放电 空间中任何地方出现的任何声音信号产生的模式。 该模型将围绕当前工作的耳蜗模型构建 分区振动（流体动​​力学）是在过去的 授予期。 该项目有 3 个具体目标。 第一个目标是 提高当前水动力模型的精度。 特别是 重要性是模型的低频部分，这似乎 需要与高频完全不同的模拟 部分。 第二个目标是通过包括以下内容来扩展模型 外周转导过程中其他部分的表示： 中耳和外耳、毛细胞转导过程、毛细胞 细胞/传入神经纤维突触和传出系统。 第三个 目的是调整模型，现在代表猫的外围，以 代表人类和小胡子蝙蝠。