STUDIES ON MODELS OF THE AUDITORY PERIPHERY

听觉外围模型的研究

• 批准号: 5209804
• 负责人: C DANIEL GEISLER
• 金额: --
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/5209804
• 关键词: acoustic nerve; auditory stimulus; biological models; cats; cochlea; ear hair cell; hearing tests; histology; human subject; laboratory rat; microelectrodes; neural information processing; noise; organ of Corti; psychoacoustics; speech; stimulus /response

The overall goal of the project is to provide an accurate and comprehensive computer model of the entire auditory periphery that will simulate the cochlear-partition macromechanical and micromechanical vibrations, the hair-cell voltages, and the auditory-nerve-fiber discharge patterns produced by any acoustic signal presented anywhere in space. This model will be built around a currently working model of cochlear- partition vibrations (hydrodynamics) that was developed during the last grant period. The project has 3 specific aims. The first aim is to improve the accuracy of the current hydrodynamic model. Of particular importance is the low-frequency section of the model, which appears to require fundamentally different simulation than does the high-frequency section. The second aim is to expand the model by including representations of other parts in the peripheral transduction process: the middle and external ears, the hair-cell transduction processes, the hair- cell/afferent-nerve-fiber synapses, and the efferent systems. The third aim is to adapt the model, now representing the cat's periphery, to represent that of the human and the mustached bat.

该项目的总体目标是提供准确的 整个听觉外围的综合计算机模型 模拟人工耳蜗宏观力学和微力机械 振动，发电池电压和听觉障碍纤维排放 由空间中任何地方呈现的任何声学信号产生的模式。 该模型将围绕着人工耳蜗的当前工作模型建立 在最后一次开发的分区振动（流体动​​力学） 赠款期。 该项目具有3个具体目标。 第一个目的是 提高当前流体动力学模型的准确性。 特别 重要性是模型的低频部分 与高频相比，需要根本不同的模拟 部分。 第二个目的是通过包括 周围换档过程中其他部分的表示： 中耳和外耳，发型细胞转导过程，头发 - 细胞/传入 - 神经纤维突触和传出系统。 第三 目的是使现在代表猫的外围的模型调整模型 代表人类和胡子蝙蝠的那些。