ACUPUNCTURE AND THE TREATMENT OF ALCOHOLISM

针灸和酗酒的治疗

• 批准号: 2874527
• 负责人: MILTON L BULLOCK
• 金额: $ 2.5万
• 依托单位: HENNEPIN HEALTHCARE RESEARCH INSTITUTE
• 依托单位国家: 美国
• 财政年份: 1994
• 资助国家: 美国
• 起止时间: 1994-08-01 至 1999-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2874527
• 关键词: acupuncture /acupressure; alcoholism /alcohol abuse therapy; alternative medicine; behavioral /social science research tag; clinical trials; craving; gender difference; human subject; human therapy evaluation

APPLICANT'S ABSTRACT: Acupuncture substance abuse treatment is being used in many treatment programs and has strong support from several investigators. Our position is that, while the results of the presently available studies are promising, additional well designed studies are needed to help confirm the impression of effectiveness before the method becomes firmly entrenched in substance abuse treatment programming. This proposal will address three basic issues in alcohol acupuncture treatment. 1. What are the relative treatment outcome size effects associated with conventional psycho-social treatment, and true, sham, and electroacupuncture?2. To what extent does placebo response contribute to conventional and acupuncture treatment outcome? 3. Are there significant, gender-related treatment outcome effects? The acupuncture treatment protocol under investigation was established in prior alcoholism research and has been pretested in three preliminary cocaine treatment studies which examined the feasibility of the treatment and placebo methods. A fully randomized, placebo controlled study will be conducted in an established residential and outpatient treatment program. Patients will be randomly assigned to one of four treatment modalities. The design will permit the comparison of true, sham, and electroacupuncture, and conventional treatment alone. All patients will receive conventional treatment. Prior to treatment, all patients will be tested for placebo responsiveness using a procedure developed for pain acupuncture research. Treatment outcome will be measured at the end of each week of treatment, at the end of treatment, and at three post treatment intervals, three months, six months and twelve months. Treatment outcome measures include self report level of craving, the Timeline Follow-Back, the composite scales of the Addiction Severity Index, confirmation using informants and document review, treatment dropout, the Medical Outcome Study Measure, Beck Depression Inventory, and Self-rating Anxiety Scale. Post-treatment utilization of medical, substance abuse and correctional system services will be noted. Measurement raters will be blinded to type of acupuncture treatment. Multivariate analyses will examine the relationship of placebo and nonspecific treatment factors to outcome, treatment effect sizes, relapse rates, and predictors of treatment outcome.

申请人摘要：针灸药物滥用治疗正在进行中 用于许多治疗方案并得到多个机构的大力支持 调查人员。 我们的立场是，虽然目前的结果 现有的研究很有希望，更多设计良好的研究正在 在使用该方法之前需要帮助确认有效性的印象 牢固地融入药物滥用治疗计划中。 该提案将解决酒精针灸的三个基本问题 治疗。 1. 相对治疗结果大小效应是什么 与传统的心理社会治疗相关，以及真实的、虚假的、 和电针？2。 安慰剂的反应程度如何 有助于常规和针灸治疗的结果吗？ 3. 是 有显着的、与性别相关的治疗结果影响吗？ 这 正在研究中的针灸治疗方案制定于 先前的酗酒研究并已在三个初步测试中进行了预先测试 可卡因治疗研究，检验了可卡因治疗的可行性 治疗和安慰剂方法。 完全随机、安慰剂对照 研究将在已建立的住院和门诊进行 治疗方案。 患者将被随机分配到四组之一 治疗方式。 该设计将允许比较真实的、 假手术、电针以及单独的常规治疗。 全部 患者将接受常规治疗。 治疗前，所有 将使用某种程序测试患者的安慰剂反应性 专为疼痛针灸研究而开发。 治疗结果将是 在每周治疗结束时测量，在治疗结束时， 以及在三个治疗后间隔、三个月、六个月和 十二个月。治疗结果衡量标准包括自我报告水平 渴望、时间线追踪、成瘾的复合量表 严重性指数，使用线人确认和文件审查， 治疗中途退出、医疗结果研究措施、贝克抑郁症 库存和焦虑自评量表。 处理后利用 医疗、药物滥用和惩教系统服务将 著名的。 测量评估者将对针灸类型不知情 治疗。 多变量分析将检查以下关系 安慰剂和非特异性治疗因素对结果、治疗效果的影响 大小、复发率和治疗结果的预测因素。