DYNAMIC POSTUROGRAPHY AND FAMILIAL HISTORY OF ALCOHOLISM

动态姿势学和酗酒家族史

• 批准号: 2682980
• 负责人: JOHN W ROHRBAUGH
• 金额: $ 19.47万
• 依托单位: WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1995
• 资助国家: 美国
• 起止时间: 1995-04-01 至 2000-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2682980
• 关键词: alcoholic beverage consumption; alcoholism /alcohol abuse; balance; biomarker; disease /disorder proneness /risk; eye movements; family genetics; human subject; middle childhood (6-11); posture; vestibuloocular reflex; young adult human (21-34)

Although it has been established that the offspring of alcoholics are themselves at increased risk for alcoholism, there is a lack of accepted markers of that risk. The proposed research will investigate the hypothesis that measures of postural steadiness provide a marker, and in addition will investigate the specific effects of acute and chronic alcohol consumption on balance mechanisms. Postural control will be studied using a dynamic posturography instrument (EquiTest, Neurocom Int.) which provides for systematic challenges to balance. This instrument will offer significant advantages over the methods that have been used in prior studies, which have consisted of measures of static ataxia rather than dynamic balance control mechanisms. The instrument measures the contributions of the visual, proprioceptive and vestibular systems to balance, and also measures motor righting responses elicited by perturbations of the platform surface. Convergent information regarding vestibular function will be obtained from a comprehensive battery of measures of oculomotor function, including positional and gaze nystagmus, optokinetic response, and pursuit and saccadic movements. Measures of postural control and eye movements will be studied in four experiments involving different groups of subjects. Subjects will be drawn from an on- going study of the genetics of alcoholism (Collaborative Study on the Genetics of Alcoholism), which provides for systematic ascertainment and assessment procedures. Experiment 1 will study preadolescent children of both sexes, with subject groups stratified according to familial density of alcoholism (and presumed accompanying risk). It is hypothesized that the children of alcoholics will show balance impairments, due in part to an over-reliance on visual sensations, and that these impairments will be in proportion to the familial density of alcoholism. Experiment 2 will investigate the dose-related effects of acute alcohol on posturographic and ocular motility measures, in young adult social drinkers. Experiment 3 will investigate the effects of alcohol challenge doses in groups of nonalcoholic male and female subjects formed on the basis of familial density of alcoholism and current levels of consumption. It is hypothesized that alcohol will exacerbate existing balance deficits in the offspring of alcoholics. Experiment 4 will study abstinent male and female chronic alcoholics, as a function of familial history, and age-matched control subjects. It is hypothesized that the postural control abilities of alcoholics will reflect the combined effects of familial and consumption histories. In all experiments the measures will yield evidence regarding the specific mechanisms involved in control of balance and the effects associated with alcohol.

尽管已经确定酗酒者的后代是 自己有酗酒的风险增加，缺乏接受 这种风险的标记。拟议的研究将调查 假设姿势稳定性提供了标记，并在 补充将研究急性和慢性的特定效果 平衡机制的饮酒。姿势控制将是 使用动态姿势仪器（Equitest，Neurocom int。）进行了研究。 这规定了有系统的挑战以平衡。该乐器将 比先前使用的方法具有显着优势 研究，包括静态共济失调的度量 动态平衡控制机制。仪器测量 视觉，本体感受和前庭系统的贡献 平衡，还测量由 平台表面的扰动。有关的收敛信息 前庭功能将从全面的电池中获得 眼动功能的度量，包括位置和凝视线stagmus， 光动力学反应以及追求和saccadic运动。措施 将在四个实验中研究姿势控制和眼动运动 涉及不同的受试者。受试者将从一个on- 对酒精中毒的遗传学进行研究（关于 酒精中毒的遗传学），提供系统的确定性和 评估程序。实验1将研究 两性，主题组根据家族密度分层 酒精中毒（并假定伴随风险）。假设 酗酒者的孩子将显示平衡障碍，部分原因是 过度依赖视觉感觉，这些障碍将是 与酒精中毒的家族密度成比例。实验2将 研究急性酒精对姿势学的剂量相关作用 年轻的成人社会饮酒者和眼动措施。实验 3将研究酒精挑战剂量的影响剂量 基于家族形成的非酒精性男性和女性受试者 酒精中毒的密度和当前的消费水平。这是 假设酒精会加剧现有的平衡不足 酗酒者的后代。实验4将研究戒律的男性和女性 慢性酗酒者是家族历史的函数，并且年龄匹配 控制对象。假设姿势控制能力 酗酒者将反映家族和 消费历史。在所有实验中，措施将产生证据 关于控制平衡和控制的具体机制 与酒精相关的影响。