Prospective Alcohol and Substance Abuse Methodology

未来酒精和药物滥用方法

• 批准号: 6487189
• 负责人: RACHEL E NABORS-OBERG
• 金额: $ 2.44万
• 依托单位: UNIVERSITY OF MISSOURI-COLUMBIA
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-06-01 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/6487189
• 关键词: alcoholic beverage consumption; alcoholism /alcohol abuse; balance; behavioral /social science research tag; clinical research; computer system design /evaluation; family genetics; female; gene environment interaction; genetic susceptibility; human data; longitudinal human study; male; method development; neuropharmacology; pathologic process; predoctoral investigator; sensorimotor system; smoking; statistics /biometry; substance abuse epidemiology; substance abuse related behavior; substance abuse related disorder; twin /multiplet; urinary tract imaging /visualization

DESCRIPTION (provided by applicant): Two projects will be conducted utilizing existing data sets from Missouri Alcohol Research Center (MARC) studies. The first data set is from a cohort-sequential study of twins from early adolescence through young adulthood. These data, taken from the Missouri Adolescent Female Twin Study in conjunction with the MARC, will be used to apply three different models used for working with longitudinal, genetically informative data in order to examine change in drinking patterns over a period of active development in drinking behavior. The models applied will be designed to uncover stable individual factors or trajectories over the course of the study duration, and to partition these variabilities into genetic and environmental components. The second data set is from a study of dynamic posturography in individuals with a family history of alcoholism. These data set will be used to illustrate the use of dynamic factor analysis, a very appropriate but underutilized tool for modeling the effects of time. The hypotheses that smoking attenuates the lagged sensory-motor responses that individuals produce in response to alcohol will be investigated. In addition, to make these analytical tools more accessible to the alcohol research community, a Visual Basic" computer program will be developed to specify and compare these models.

描述（由申请人提供）：将通过两个项目进行使用 密苏里酒精研究中心（MARC）研究的现有数据集。这 第一个数据集来自早期对双胞胎的队列顺序研究 青春期成年的青春期。这些数据，取自密苏里州 青少年女性双胞胎研究与MARC结合 应用三种不同的模型，用于使用纵向，遗传学 信息丰富的数据以检查一段时间内饮酒模式的变化 饮酒行为积极发展。应用的模型将是 旨在发现课程中稳定的个体因素或轨迹 研究持续时间，并将这些变异性划分为遗传和 环境组成部分。 第二个数据集来自对个体动态姿势的研究 有酗酒的家族史。这些数据集将用于说明 动态因素分析的使用，这是一种非常适当但未充分利用的工具 用于建模时间的影响。假设吸烟会削弱 个人根据酒精产生的滞后感觉运动反应 将被调查。此外，要使这些分析工具更多 酒精研究社区可访问，这是一个视觉基本的“计算机程序” 将开发以指定和比较这些模型。