Development of brain activity and motor control in early human life

人类早期大脑活动和运动控制的发展

基本信息

批准号：
MR/P008712/1
负责人：
Tomoki Arichi
金额：
$ 140.82万
依托单位：
King's College London
依托单位国家：
英国
项目类别：
Fellowship
财政年份：
2017
资助国家：
英国
起止时间：
2017 至无数据
项目状态：
已结题

来源：
https://gtr.ukri.org/projects?ref=MR%2FP008712%2F1
关键词：
Development brain activity motor control

项目摘要

An injury to the brain during the crucial stages of early life in the womb and around the time of birth can lead to life-long difficulties with brain function. Damage to the specific areas of the brain which control how the body moves at this time can result in cerebral palsy, which can consist of permanent limb paralysis or uncontrolled movements. There is no cure for cerebral palsy, perhaps due to a fundamental lack of knowledge about how the brain and its activity actually develops control over how the body moves in the earliest stages of life. Furthermore, current medical tests cannot accurately identify which babies will develop cerebral palsy later in childhood, which means that doctors cannot start early treatment and leaving families with several months of stressful uncertainty. Right from the earliest stages of pregnancy, babies can be seen and felt to be moving inside the womb. After birth, they continue to move in a seemingly random way until 6 months of age when they begin to make clearer controlled and purposeful movements. Previous studies suggest that even at this early stage, the brain can alter how it controls movement through simple learning. In this early period of life, the human brain is undergoing more dramatic changes in size, shape, and structure than at any other time, and therefore there must also be enormous changes in how its activity evolves to allow these new patterns of movement. I therefore plan to use specialist techniques to precisely measure how babies move (both inside and outside the womb) and then identify and locate the accompanying brain activity. I will study how this changes as a baby grows during their first 6 months, and explore how the relationship is affected by early brain injury. Finally I will try to understand how brain activity and movements can be altered by stimulation through learning. The results of these studies will provide new and important insights about how the brain matures through and then controls movements in the first year. This fundamental knowledge will help doctors and scientists understand how to try and ensure healthy brain development and movements in early life. It will also help them to diagnose, potentially prevent and treat conditions like cerebral palsy which affect the control of movement in children.

在子宫内生命早期的关键阶段和出生前后的大脑损伤可能会导致大脑功能终身困难。此时控制身体运动方式的大脑特定区域受损可能会导致脑瘫，包括永久性肢体瘫痪或不受控制的运动。脑瘫无法治愈，可能是因为人们根本不了解大脑及其活动如何在生命的最初阶段对身体的运动进行控制。此外，目前的医学测试无法准确识别哪些婴儿会在童年后期患上脑瘫，这意味着医生无法开始早期治疗，给家庭带来几个月的压力和不确定性。从怀孕的最初阶段起，就可以看到并感觉到婴儿在子宫内移动。出生后，他们继续以看似随机的方式移动，直到 6 个月大时，他们开始做出更清晰的受控和有目的的动作。先前的研究表明，即使在这个早期阶段，大脑也可以通过简单的学习来改变它控制运动的方式。在生命的早期阶段，人类大脑的大小、形状和结构正在经历比任何其他时期都更加剧烈的变化，因此其活动的进化方式也必须发生巨大的变化，以允许这些新的运动模式。因此，我计划使用专业技术来精确测量婴儿如何移动（在子宫内和子宫外），然后识别和定位伴随的大脑活动。我将研究随着婴儿在前 6 个月的成长，这种关系如何变化，并探讨早期脑损伤如何影响这种关系。最后，我将尝试了解如何通过学习刺激来改变大脑活动和运动。这些研究的结果将为大脑如何在第一年成熟并控制运动提供新的重要见解。这些基础知识将帮助医生和科学家了解如何尝试并确保生命早期健康的大脑发育和运动。它还将帮助他们诊断、预防和治疗影响儿童运动控制的脑瘫等疾病。

项目成果

期刊论文数量（10）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Development of neonatal-specific sequences for portable ultralow field magnetic resonance brain imaging: a prospective, single-centre, cohort study

用于便携式超低场磁共振脑成像的新生儿特异性序列的开发：一项前瞻性、单中心、队列研究

DOI：
http://dx.10.1016/j.eclinm.2023.102253
发表时间：
2023
期刊：
eClinicalMedicine
影响因子：
15.1
作者：
Cawley P
通讯作者：
Cawley P

Complementing cooling: the ongoing search for an effective adjunct to therapeutic hypothermia.

补充冷却：持续寻找治疗性低温的有效辅助手段。

DOI：
http://dx.10.1113/jp279518
发表时间：
2020
期刊：
The Journal of physiology
影响因子：
0
作者：
Baburamani AA
通讯作者：
Baburamani AA

Care in COVID: A qualitative analysis of the impact of COVID-19 on the health and care of children and young people with severe physical neurodisability and their families.

COVID 护理：定性分析 COVID-19 对患有严重身体神经障碍的儿童和青少年及其家人的健康和护理的影响。

DOI：
http://dx.10.1111/cch.12925
发表时间：
2022
期刊：
care, health and development
影响因子：
0
作者：
Cadwgan J
通讯作者：
Cadwgan J

Localization of spontaneous bursting neuronal activity in the preterm human brain with simultaneous EEG-fMRI.

通过同步 EEG-fMRI 定位早产人大脑中的自发爆发神经元活动。

DOI：
http://dx.10.7554/elife.27814
发表时间：
2017
期刊：
eLife
影响因子：
7.7
作者：
Arichi T
通讯作者：
Arichi T

The developing brain structural and functional connectome fingerprint

发育中的大脑结构和功能连接组指纹

DOI：
10.1016/j.dcn.2022.101117
发表时间：
2022-06
期刊：
Developmental Cognitive Neuroscience
影响因子：
4.7
作者：
Ciarrusta, Judit;Christiaens, Daan;Fitzgibbon, Sean P.;Dimitrova, Ralica;Hutter, Jana;Hughes, Emer;Duff, Eugene;Price, Anthony N.;Cordero-Grande, Lucilio;Tournier, J. -Donald;Rueckert, Daniel;V. Hajnal, Joseph;Arichi, Tomoki;McAlonan, Grainne;Edwards, David;Batalle, Dafnis
通讯作者：
Batalle, Dafnis