3DBioNet: an integrated technological platform for 3D micro-tissues

3DBioNet：3D微组织集成技术平台

基本信息

批准号：
MR/R025762/1
负责人：
Raphael Levy
金额：
$ 79.77万
依托单位：
University of Liverpool
依托单位国家：
英国
项目类别：
Research Grant
财政年份：
2018
资助国家：
英国
起止时间：
2018 至无数据
项目状态：
已结题

来源：
https://gtr.ukri.org/projects?ref=MR%2FR025762%2F1
关键词：
3DBioNet integrated technological platform 3D

项目摘要

Maybe you have already seen cells under a microscope? Plants, animals and humans are made of cells. For approximately a century, scientists have routinely grown cells on flat transparent surfaces (glass or plastic). Growing cells on flat surfaces is very convenient. In fact, it has been so successful that a lot of what we know about cell components such as the nucleus (which contains the genetic information) and mitonchodria (which provides energy) comes from such experiments; this also includes discovery of drugs and tests of their potential toxicity. However, in real living organisms cells are not attached to a flat surface. Instead, they interact with their three dimensional environment which includes other cells as well as factors secreted by cells. Scientists now realize more and more the importance of this difference between growing cells on a flat surface or growing them in 3D: it modifies their shape, how they communicate with each others and how they respond to changes in their environment. Until recently, animal experiments have been the main alternative to cells grown on flat surfaces. Whilst animal experiments remain essential to our understanding of biology and to the discovery of new drugs, they do not perfectly mimic human biology and it is also desirable to reduce their number for ethical reasons.In the last decade, scientists have started to culture cells in 3D thereby producing micro-tissues, often starting from stem cells. These micro-tissues made of human-derived cells resemble human tissues. But, just like going from 2D printing to 3D printing requires new materials, new software, new ideas and new procedures, going from 2D cell culture to 3D cell culture requires a large number of innovations in the methods, materials and technologies that scientists use to design, perform, analyse and interpret their experiments. The purpose of the 3DbioNet network is to bring together the skills of scientists from many different disciplines within academia and industry needed to identify the stumbling blocks and help building this new way of doing biology.

也许您已经在显微镜下看到了细胞？植物，动物和人类是由细胞制成的。大约一个世纪以来，科学家在平坦的透明表面（玻璃或塑料）上定期生长细胞。在平面上生长的细胞非常方便。实际上，它是如此成功，以至于我们对细胞成分（包括遗传信息）和Mitonchodria（提供能量）等细胞成分的了解都来自此类实验。这还包括发现药物以及对其潜在毒性的测试。但是，在实际生物中，细胞不连接到平坦的表面。取而代之的是，它们与包括其他细胞的三维环境以及细胞分泌的因素相互作用。现在，科学家们越来越意识到这种差异在平坦的表面上生长或以3D生长之间的重要性：它改变了它们的形状，如何与彼此交流以及它们如何应对环境的变化。直到最近，动物实验一直是在平坦表面生长的细胞的主要替代方法。尽管动物实验对于我们对生物学的理解和发现新药仍然至关重要，但它们并不能完全模仿人类的生物学，也希望出于道德原因减少其数量。过去十年中，科学家已经开始在3D中培养细胞，从而产生微细胞，通常从干细胞开始。这些由人类衍生细胞制成的微型组织类似于人体组织。但是，就像从2D打印到3D打印需要新材料，新软件，新想法和新程序一样，从2D细胞培养到3D细胞文化也需要科学家用来设计，执行，分析和解释其实验的方法，材料和技术的大量创新。 3DBIONET网络的目的是将学术界和行业中许多不同学科的科学家的技能汇集在一起，以确定绊脚石，并帮助建立这种新的生物学方式。

项目成果

期刊论文数量（10）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Quantification of the nonlinear susceptibility of the hydrogen and deuterium stretch vibration for biomolecules in coherent Raman micro-spectroscopy.

DOI：
10.1002/jrs.6164
发表时间：
2021-09
期刊：
JOURNAL OF RAMAN SPECTROSCOPY
影响因子：
2.5
作者：
Boorman, Dale;Pope, Iestyn;Masia, Francesco;Watson, Peter;Borri, Paola;Langbein, Wolfgang
通讯作者：
Langbein, Wolfgang

An insight into the iPSCs-derived two-dimensional culture and three-dimensional organoid models for neurodegenerative disorders.

DOI：
10.1098/rsfs.2022.0040
发表时间：
2022-10-06
期刊：
Interface focus
影响因子：
4.4
作者：
通讯作者：

A Systematic Comparative Assessment of the Response of Ovarian Cancer Cells to the Chemotherapeutic Cisplatin in 3D Models of Various Structural and Biochemical Configurations-Does One Model Type Fit All?

DOI：
10.3390/cancers14051274
发表时间：
2022-03-01
期刊：
Cancers
影响因子：
5.2
作者：
Gupta P;Miller A;Olayanju A;Madhuri TK;Velliou E
通讯作者：
Velliou E

In vitro and in silico approaches to engineering three-dimensional biological tissues and organoids

DOI：
10.1098/rsfs.2022.0046
发表时间：
2022-08-12
期刊：
Interface Focus
影响因子：
4.4
作者：
通讯作者：

Tailoring the biofunctionality of collagen biomaterials via tropoelastin incorporation and EDC-crosslinking.

DOI：
10.1016/j.actbio.2021.08.027
发表时间：
2021-08
期刊：
Acta biomaterialia
影响因子：
9.7
作者：
D. Bax;Malavika Nair;A. Weiss;R. Farndale;S. Best;R. Cameron
通讯作者：
D. Bax;Malavika Nair;A. Weiss;R. Farndale;S. Best;R. Cameron

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Raphael Levy其他文献

Caractéristiques en imagerie des sous-groupes d’épendymomes de fosse postérieure

DOI：
10.1016/j.neurad.2023.01.039
发表时间：
2023-03-01
期刊：
Conference abstract
影响因子：
作者：
Volodia Dangouloff-Ros;Thomas Leclerc;Raphael Levy;Charles-Joris Roux;Nathalie Boddaert
通讯作者：
Nathalie Boddaert

Etude neuroradiologique du syndrome CMMRD et comparaison en imagerie de tumeurs gliales de haut grade selon le statut MMR

DOI：
10.1016/j.neurad.2023.01.046
发表时间：
2023-03-01
期刊：
Conference abstract
影响因子：
作者：
Magali Raveneau;Volodia Dangouloff-Ross;Charles-Joris Roux;Raphael Levy;Lea Guerrini-Rousseau;Annick Sevely;Jean Darcourt;Fabrice Bonneville;Nathalie Boddaert
通讯作者：
Nathalie Boddaert